Bioactive sesquiterpenoids from the flowers of Inula japonica
文献类型：期刊论文
| 作者 | Wu, Xing-De; Ding, Lin-Fen; Tu, Wen-Chao; Yang, Hui; Su, Jia; Peng, Li-Yan; Li, Yan ; Zhao, Qin-Shi
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2016-09-01 |
| 卷号 | 129页码:68-76 |
| 关键词 | Inula japonica Asteraceae Sesquiterpenoids Inujaponins A-I Cytotoxicity Nitric oxide (NO) |
| 英文摘要 | Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-K alpha Xray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL 60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 mu M. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 mu M. (C) 2016 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | NITRIC-OXIDE PRODUCTION ; LACTONES ; BRITANNICA ; CONSTITUENTS ; THUNB |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000381832900007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/28575]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu, Xing-De,Ding, Lin-Fen,Tu, Wen-Chao,et al. Bioactive sesquiterpenoids from the flowers of Inula japonica[J]. PHYTOCHEMISTRY,2016,129:68-76. |
| APA | Wu, Xing-De.,Ding, Lin-Fen.,Tu, Wen-Chao.,Yang, Hui.,Su, Jia.,...&Zhao, Qin-Shi.(2016).Bioactive sesquiterpenoids from the flowers of Inula japonica.PHYTOCHEMISTRY,129,68-76. |
| MLA | Wu, Xing-De,et al."Bioactive sesquiterpenoids from the flowers of Inula japonica".PHYTOCHEMISTRY 129(2016):68-76. |
入库方式： OAI收割
来源：昆明植物研究所
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