Bioactive ent-kaurane diterpenoids from Isodon serra
文献类型：期刊论文
| 作者 | Wan, Jun; Liu, Miao; Jiang, Hua-Yi; Yang, Jin; Du, Xue; Li, Xiao-Nian; Wang, Wei-Guang; Li, Yan ; Pu, Jian-Xin; Sun, Han-Dong
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2016-10-01 |
| 卷号 | 130页码:244-251 |
| 关键词 | Isodon serra Lamiaceae 7,20-Epoxy-ent-kaurane diterpenoids Cytotoxic activity Anti-inflammatory |
| 英文摘要 | Nine 7,20-epoxy-ent-kaurane diterpenoids (15-acetylmegathyrin B, serrin E, 14 beta-hydroxyrabdocoestin A, serrin F, serrin G, 11-epi-rabdocoestin A, serrin H, serrin I, and 15-acetylenanderianin N), along with seven known ones, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 15-acetylmegathyrin B was determined by signal-crystal X-ray diffraction. All of these compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). Serrin F, rabdocoestin B and 1 alpha,11 beta-dihydroxy-1 alpha,11 beta-acetonide-7 alpha,20-epoxy-ent-kaur-16-en-15-one showed cytotoxic activities against all cell lines, with IC50 values ranging from 0.7 to 4.6 mu M; serrin F also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. Otherwise, 14 beta-hydroxyrabdocoestin A, serrins H and I, as well as enanderianin N and megathyrin B, also exhibited inhibitory effects towards NO production, while no cytotoxicity against five cell lines was detected. (C) 2016 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | CYTOTOXIC DITERPENOIDS ; MEGATHYRSUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383302900024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/28604]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wan, Jun,Liu, Miao,Jiang, Hua-Yi,et al. Bioactive ent-kaurane diterpenoids from Isodon serra[J]. PHYTOCHEMISTRY,2016,130:244-251. |
| APA | Wan, Jun.,Liu, Miao.,Jiang, Hua-Yi.,Yang, Jin.,Du, Xue.,...&Sun, Han-Dong.(2016).Bioactive ent-kaurane diterpenoids from Isodon serra.PHYTOCHEMISTRY,130,244-251. |
| MLA | Wan, Jun,et al."Bioactive ent-kaurane diterpenoids from Isodon serra".PHYTOCHEMISTRY 130(2016):244-251. |
入库方式： OAI收割
来源：昆明植物研究所
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