Isolation and Asymmetric Total Synthesis of Perforanoid A
文献类型：期刊论文
| 作者 | Lv, Chao; Yan, Xiaohui; Tu, Qian; Di, Yingtong ; Yuan, Chunmao; Fang, Xin; Ben-David, Yaacove; Xia, Lei; Gong, Jianxian; Shen, Yuemao
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2016-06-20 |
| 卷号 | 55期号:26页码:7539-7543 |
| 关键词 | asymmetric synthesis cytotoxicity limonoids Pauson-Khand reaction total synthesis |
| 英文摘要 | A novel limonoid, perforanoid A, was isolated, and an asymmetric total synthesis was achieved in 10 steps. The key steps are chiral tertiary aminonaphthol mediated enantioselective alkenylation of an aldehyde to an allylic alcohol, Pd-catalyzed coupling of the allylic alcohol with vinyl ether to form the gamma-lactone ring, and cyclopentenone ring formation through a Rh-catalyzed Pauson-Khand reaction. Preliminary studies show that perforanoid A is cytotoxic towards HEL, K562, and CB3 tumor cell lines. |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | OSHIMA-UTIMOTO REACTION ; ALKENYL GRIGNARD-REAGENTS ; CROSS-COUPLING REACTIONS ; ALKYL-HALIDES ; BIOLOGICAL-ACTIVITIES ; LIMONOIDS ; FRAXINELLONE ; AZADIRACHTIN ; INHIBITOR ; CHEMISTRY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383077400042 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/28626]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Lv, Chao,Yan, Xiaohui,Tu, Qian,et al. Isolation and Asymmetric Total Synthesis of Perforanoid A[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(26):7539-7543. |
| APA | Lv, Chao.,Yan, Xiaohui.,Tu, Qian.,Di, Yingtong.,Yuan, Chunmao.,...&Hao, Xiaojiang.(2016).Isolation and Asymmetric Total Synthesis of Perforanoid A.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(26),7539-7543. |
| MLA | Lv, Chao,et al."Isolation and Asymmetric Total Synthesis of Perforanoid A".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.26(2016):7539-7543. |
入库方式： OAI收割
来源：昆明植物研究所
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