Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia
文献类型：期刊论文
| 作者 | Li, Ping1; AnandhiSenthilkumar, Harini2,3,4; Wu, Shi-biao2; Liu, Bo1; Guo, Zhi-yong1; Fata, Jimmie E.3,5; Kennelly, Edward J.1,2,3; Long, Chun-lin1 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 1011期号:1页码:179-195 |
| 关键词 | Garcinia oblongifolia UPLC-QTOF-MS PCA Cytotoxicity Antioxidants Xanthones Benzophenones Biflavonones |
| 英文摘要 | Garcinia oblongifolia Champ. ex Benth. (Clusiaceae) is a well-known medicinal plant from southern China, with edible fruits. However, the phytochemistry and bioactivity of the different plant parts of G. oblongifolia have not been studied extensively. Comparative metabolic profiling and bioactivities of the leaf, branch, and fruit of G. oblongifolia were investigated. A total of 40 compounds such as biflavonoids, xanthones, and benzophenones were identified using UPLC-QTOF-MS and MSE, including 15 compounds reported for the first time from this species. Heatmap analyses found that benzophenones, xanthones, and biflavonoids were predominately found in branches, with benzophenones present in relatively high concentrations in all three plant parts. Xanthones were found to have limited distribution in fruit while biflavonoids were present at only low levels in leaves. In addition, the cytotoxic (MCF-7 breast cancer cell line) and antioxidant (ABTS and DPPH chemical tests) activities of the crude extracts of G. oblongifolia indicate that the branch extract exhibits greater bioactivity than either the leaf or the fruit extracts. Orthogonal partial least squares discriminate analysis was used to find 12 marker compounds, mainly xanthones, from the branches, including well-known antioxidants and cytotoxic agents. These G. oblongifolia results revealed that the variation in metabolite profiles can be correlated to the differences in bioactivity of the three plant parts investigated. This UPLC-QTOF-MS strategy can be useful to identify bioactive constituents expressed differentially in the various plant parts of a single species. (C) 2016 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Biochemical Research Methods ; Chemistry, Analytical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | TANDEM MASS-SPECTROMETRY ; PRENYLATED XANTHONES ; POLYPRENYLATED XANTHONES ; ANTIOXIDANT ACTIVITY ; PHENOLIC-COMPOUNDS ; CAGED XANTHONES ; BARK ; IDENTIFICATION ; BENZOPHENONES ; MANGOSTANA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369458600024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25938]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China 2.CUNY Herbert H Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA 3.CUNY, Grad Ctr, Biochem Biol & Chem PhD Programs, New York, NY 10016 USA 4.CUNY Coll Staten Isl, Dept Biol Sci, Staten Isl, NY 10314 USA 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ping,AnandhiSenthilkumar, Harini,Wu, Shi-biao,et al. Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2016,1011(1):179-195. |
| APA | Li, Ping.,AnandhiSenthilkumar, Harini.,Wu, Shi-biao.,Liu, Bo.,Guo, Zhi-yong.,...&Long, Chun-lin.(2016).Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1011(1),179-195. |
| MLA | Li, Ping,et al."Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1011.1(2016):179-195. |
入库方式： OAI收割
来源：昆明植物研究所
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