The metabolism and biotechnological application of betaine in microorganism
文献类型：期刊论文
| 作者 | Zou, Huibin1,2; Chen, Ningning1; Shi, Mengxun1; Xian, Mo2 ; Song, Yimin1; Liu, Junhong1
|
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 100期号:9页码:3865-3876 |
| 关键词 | Glycine betaine Metabolic pathways Metabolic engineering One-carbon metabolism Methyl group metabolism Secondary metabolites |
| 英文摘要 | Glycine betaine (betaine) is widely distributed in nature and can be found in many microorganisms, including bacteria, archaea, and fungi. Due to its particular functions, many microorganisms utilize betaine as a functional chemical and have evolved different metabolic pathways for the biosynthesis and catabolism of betaine. As in animals and plants, the principle role of betaine is to protect microbial cells against drought, osmotic stress, and temperature stress. In addition, the role of betaine in methyl group metabolism has been observed in a variety of microorganisms. Recent studies have shown that betaine supplementation can improve the performance of microbial strains used for the fermentation of lactate, ethanol, lysine, pyruvate, and vitamin B-12, during which betaine can act as stress protectant or methyl donor for the biosynthesis of structurally complex compounds. In this review, we summarize the transport, synthesis, catabolism, and functions of betaine in microorganisms and discuss potential engineering strategies that employ betaine as a methyl donor for the biosynthesis of complex secondary metabolites such as a variety of vitamins, coenzymes, and antibiotics. In conclusion, the biocompatibility, C/N ratio, abundance, and comprehensive metabolic information of betaine collectively indicate that this molecule has great potential for broad applications in microbial biotechnology. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | INDEPENDENT METHIONINE SYNTHASE ; OSMOPROTECTANT GLYCINE BETAINE ; BIOSYNTHETIC GENE-CLUSTER ; ESCHERICHIA-COLI STRAIN ; TRANSPORT-SYSTEM ; METHANOHALOPHILUS-PORTUCALENSIS ; CORYNEBACTERIUM-GLUTAMICUM ; VOLUMETRIC PRODUCTIVITY ; METHYLTRANSFERASE GENES ; PSEUDOMONAS-AERUGINOSA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000373744000006 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/8256]  |
| 专题 | 青岛生物能源与过程研究所_材料生物技术研究中心 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Huibin,Chen, Ningning,Shi, Mengxun,et al. The metabolism and biotechnological application of betaine in microorganism[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2016,100(9):3865-3876. |
| APA | Zou, Huibin,Chen, Ningning,Shi, Mengxun,Xian, Mo,Song, Yimin,&Liu, Junhong.(2016).The metabolism and biotechnological application of betaine in microorganism.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,100(9),3865-3876. |
| MLA | Zou, Huibin,et al."The metabolism and biotechnological application of betaine in microorganism".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100.9(2016):3865-3876. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。