Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels
文献类型：期刊论文
| 作者 | You, Jun1,2,3 ; Cao, Jinfeng1,2; Zhao, Yanteng4; Zhang, Lina1,2; Zhou, Jinping1,2; Chen, Yun4
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| 刊名 | BIOMACROMOLECULES
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| 出版日期 | 2016-09-01 |
| 卷号 | 17期号:9页码:2839-2848 |
| 英文摘要 | Polysaccharide-based injectable hydrogels have several advantages in the context of biomedical use. However, the main obstruction associated with the utilization of these hydrogels in clinical application is their poor mechanical properties. Herein, we describe in situ gelling of nanocomposite hydrogels based on quaternized cellulose (QC) and rigid rod-like cationic cellulose nanocrystals (CCNCs), which can overcome,this challenge. In all cases, gelation immediately occurred with an increase of temperature, and the CCNCs were evenly distributed, throughout the hydrogels. The nanocomposite hydrogels exhibited increasing orders-of-magnitude in-the mechanical strength, high extension in degradation and the sustained release time, because of the strong interaction between CCNCs and QC chains mediated by the cross-linking agent (beta-glycerophosphate, beta-GP). The results of the in vitro toxicity and in vivo biocompatibility tests revealed that the hydrogels did :not show obvious cytotoxicity and inflammatory reaction to cells and tissue: Moreover, DOX-encapsulated hydrogels were injected beside the tumors of mice bearing liver cancer xenografts to assess the potential utility as localized and sustained drug delivery depot systems for anticancer therapy. The results suggested that the QC/CCNC/beta-GP nanocomposite hydrogels had great potential for application in subcutaneous and sustained delivery of anticancer drug to increase therapeutic efficacy and improve patient compliance. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 关键词[WOS] | NANOCOMPOSITE HYDROGELS ; QUATERNIZED CELLULOSE ; DRUG-DELIVERY ; POLY(ETHYLENE GLYCOL) ; REGENERATIVE MEDICINE ; SILICA NANOPARTICLE ; PROTEIN-RELEASE ; CROSS-LINKING ; TISSUE ; NANOWHISKERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383213200008 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/8530]  |
| 专题 | 青岛生物能源与过程研究所_仿生智能材料团队 |
| 作者单位 | 1.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China 2.Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 4.Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | You, Jun,Cao, Jinfeng,Zhao, Yanteng,et al. Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels[J]. BIOMACROMOLECULES,2016,17(9):2839-2848. |
| APA | You, Jun,Cao, Jinfeng,Zhao, Yanteng,Zhang, Lina,Zhou, Jinping,&Chen, Yun.(2016).Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels.BIOMACROMOLECULES,17(9),2839-2848. |
| MLA | You, Jun,et al."Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels".BIOMACROMOLECULES 17.9(2016):2839-2848. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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