X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization
文献类型：期刊论文
| 作者 | Fan, Wenpei1; Bu, Wenbo1; Zhang, Zhen2; Shen, Bo3; Zhang, Hui2; He, Qianjun1; Ni, Dalong1; Cui, Zhaowen1; Zhao, Kuaile2; Bu, Jiwen4 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-11-16 |
| 卷号 | 54期号:47页码:14026-14030 |
| 关键词 | hypoxic radiosensitization luminescent imaging NO release on-demand therapy X-ray radiation |
| 英文摘要 | Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | UP-CONVERSION NANOPARTICLES ; ANTICANCER DRUG-DELIVERY ; NITRIC-OXIDE ; BIOMEDICAL APPLICATIONS ; SILICA NANOPARTICLES ; MESOPOROUS SILICA ; CANCER-THERAPY ; NANOTHERANOSTICS ; NANOPHOSPHORS ; RADIOTHERAPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367722500031 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/8193]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China 3.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Wenpei,Bu, Wenbo,Zhang, Zhen,et al. X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(47):14026-14030. |
| APA | Fan, Wenpei.,Bu, Wenbo.,Zhang, Zhen.,Shen, Bo.,Zhang, Hui.,...&Shi, Jianlin.(2015).X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(47),14026-14030. |
| MLA | Fan, Wenpei,et al."X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.47(2015):14026-14030. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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