Preparation, physicochemical properties and in vitro bioactivity of hierarchically porous bioactive glass scaffolds
文献类型：期刊论文
| 作者 | Wang, Xiaocheng; Shi, Mengchao; Zhai, Dong; Wu, Chengtie |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:120页码:98796-98804 |
| 英文摘要 | Exploring bioactive scaffolds with the desired architecture and high osteogenic capacity has been a challenging issue for biomaterials and bone tissue engineering. Herein, a hierarchically porous bioactive glass scaffold (noted as YMBG) has been prepared by using P123, yeast cells and polyurethane sponges as templates. This synthesis strategy created high porosity scaffolds with interconnected macropores (300-500 mm), well-ordered mesopores (similar to 5 nm) and mid-level pores (20 nm to 2 mm). The utilization of yeast cells as a midpore biotemplate in the scaffolds significantly promoted the crystallization and improved their mechanical strengths. In addition, the prepared scaffolds could support attachment and proliferation of BMSCs, and more importantly, significantly improved the expression of bone-related genes (Runx2, OCN, Col I and BMP2). The results suggest that the novel bioactive glass scaffolds with widely-distributed porous structures, which can be employed as an effective carrier for a variety of therapeutic molecules and tissue cells, are expected to be a promising biomaterial for bone regeneration and tissue engineering. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | GENE-EXPRESSION ; IMMOBILIZATION ; BIOMATERIALS ; REGENERATION ; EFFICIENCY ; STIFFNESS ; STRENGTH ; BEHAVIOR ; LIPASE ; SBA-15 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365328000009 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/8706]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaocheng,Shi, Mengchao,Zhai, Dong,et al. Preparation, physicochemical properties and in vitro bioactivity of hierarchically porous bioactive glass scaffolds[J]. RSC ADVANCES,2015,5(120):98796-98804. |
| APA | Wang, Xiaocheng,Shi, Mengchao,Zhai, Dong,&Wu, Chengtie.(2015).Preparation, physicochemical properties and in vitro bioactivity of hierarchically porous bioactive glass scaffolds.RSC ADVANCES,5(120),98796-98804. |
| MLA | Wang, Xiaocheng,et al."Preparation, physicochemical properties and in vitro bioactivity of hierarchically porous bioactive glass scaffolds".RSC ADVANCES 5.120(2015):98796-98804. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。