Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses
文献类型：期刊论文
| 作者 | Shi, Yi1,2; Zhang, Wei2,3; Wang, Fei2,4; Qi, Jianxun2; Wu, Ying2; Song, Hao2,3; Gao, Feng5; Bi, Yuhai2; Zhang, Yanfang6; Fan, Zheng7 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2013-10-11 |
| 卷号 | 342期号:6155页码:243-247 |
| 英文摘要 | An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) -> Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | A VIRUS ; CONFORMATIONAL-ANALYSIS ; HUMAN CONJUNCTIVITIS ; TRANSMISSION ; SPECIFICITY ; ORIGIN ; SIALYLOLIGOSACCHARIDES ; COMPLEXES ; SELECTION ; OUTBREAK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325475200044 |
| 源URL | [http://124.16.173.210/handle/834782/1268]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Lab Noncoding RNA, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China 7.Chinese Acad Sci, Inst Microbiol, Core Facil, Beijing 100101, Peoples R China 8.Beijing Inst Microbiol & Epidemiol, Dept Virol, Beijing 100071, Peoples R China 9.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China 10.China CDC, Off Director Gen, Beijing 102206, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Yi,Zhang, Wei,Wang, Fei,et al. Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses[J]. SCIENCE,2013,342(6155):243-247. |
| APA | Shi, Yi.,Zhang, Wei.,Wang, Fei.,Qi, Jianxun.,Wu, Ying.,...&Gao, George F..(2013).Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses.SCIENCE,342(6155),243-247. |
| MLA | Shi, Yi,et al."Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses".SCIENCE 342.6155(2013):243-247. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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