Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division
文献类型：期刊论文
| 作者 | Shi, Zhongyu1,2; Xuan, Chunling1,2; Han, Huiming1; Cheng, Xia1,3; Wang, Jundong3; Feng, Youjun4; Srinivas, Swaminath5; Lu, Guangwen1; Gao, George F.1,2,6,7 |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 5期号:10页码:761-769 |
| 关键词 | Streptococcus suis Ga5DH cell shape cell division FtsZ localization |
| 英文摘要 | Bacterial cell division is strictly regulated in the formation of equal daughter cells. This process is governed by a series of spatial and temporal regulators, and several new factors of interest to the field have recently been identified. Here, we report the requirement of gluconate 5-dehydrogenase (Ga5DH) in cell division of the zoonotic pathogen Streptococcus suis. Ga5DH catalyzes the reversible reduction of 5-ketogluconate to D-gluconate and was localized to the site of cell division. The deletion of Ga5DH in S. suis resulted in a plump morphology with aberrant septa joining the progeny. A significant increase was also observed in cell length. These defects were determined to be the consequence of Ga5DH deprivation in S. suis causing FtsZ delocalization. In addition, the interaction of FtsZ with Ga5DH in vitro was confirmed by protein interaction assays. These results indicate that Ga5DH may function to prevent the formation of ectopic Z rings during S. suis cell division. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | TOXIC-SHOCK-SYNDROME ; ESCHERICHIA-COLI ; SEROTYPE-2 ; INFECTION ; VARIANTS ; MUTANTS ; PROTEIN ; ROLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343055700005 |
| 源URL | [http://124.16.173.210/handle/834782/1365]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanxi Agr Univ, Coll Anim Sci & Technol, Taigu 030801, Peoples R China 4.Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA 5.Univ Illinois, Dept Biochem, Urbana, IL 61801 USA 6.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin 300308, Peoples R China 7.Chinese Acad Sci, Beijing Inst Life Sci, RNIH, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Zhongyu,Xuan, Chunling,Han, Huiming,et al. Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division[J]. PROTEIN & CELL,2014,5(10):761-769. |
| APA | Shi, Zhongyu.,Xuan, Chunling.,Han, Huiming.,Cheng, Xia.,Wang, Jundong.,...&Gao, George F..(2014).Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division.PROTEIN & CELL,5(10),761-769. |
| MLA | Shi, Zhongyu,et al."Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division".PROTEIN & CELL 5.10(2014):761-769. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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