Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients
文献类型：期刊论文
| 作者 | Huang, Fengming1; Guo, Jing2,3; Zou, Zhen1; Liu, Jun4,5; Cao, Bin6; Zhang, Shuyang7,8,9; Li, Hui6; Wang, Wei1; Sheng, Miaomiao1; Liu, Song1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 5 |
| 英文摘要 | A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin-angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO(2) ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | A H7N9 VIRUS ; COMMUNITY-ACQUIRED PNEUMONIA ; ACUTE LUNG INJURY ; CLASSIFICATION-SYSTEM ; ALDOSTERONE SYSTEM ; CONVERTING ENZYME ; HUMAN INFECTIONS ; HUMAN HEALTH ; H1N1 VIRUS ; APACHE-II |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337361600003 |
| 源URL | [http://124.16.173.210/handle/834782/1414]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Chinese Acad Med Sci, Tsinghua Univ, Peking Union Med Coll, Inst Basic Med Sci,Dept Biochem,State Key Lab Med, Beijing 100005, Peoples R China 2.Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China 3.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 5.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China 6.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China 7.Beijing Union Med Coll Hosp, Peking Union Med Coll, Ctr Translat Med, Beijing 100730, Peoples R China 8.Chinese Acad Med Sci, Beijing 100730, Peoples R China 9.Beijing Union Med Coll Hosp, Peking Union Med Coll, Dept Cardiol, Beijing 100730, Peoples R China 10.Hangzhou Ctr Dis Control & Prevent, Hangzhou 310021, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Fengming,Guo, Jing,Zou, Zhen,et al. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients[J]. NATURE COMMUNICATIONS,2014,5. |
| APA | Huang, Fengming.,Guo, Jing.,Zou, Zhen.,Liu, Jun.,Cao, Bin.,...&Li, Lanjuan.(2014).Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients.NATURE COMMUNICATIONS,5. |
| MLA | Huang, Fengming,et al."Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients".NATURE COMMUNICATIONS 5(2014). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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