The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
文献类型：期刊论文
| 作者 | Guo, Jing1,2; Huang, Fengming3; Liu, Jun4; Chen, Yu1,2; Wang, Wei3; Cao, Bin5; Zou, Zhen3; Liu, Song3; Pan, Jingcao6; Bao, Changjun7 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 5 |
| 英文摘要 | The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers predicting the progression of disease and fatal outcome of potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 of the 48 cytokines and chemokines examined in this study were significantly elevated in the plasma samples from patients infected with H7N9. We report for the first time that the levels of MIF, SCF, MCP-1, HGF, and SCGF-beta are highly positively linked to disease severity and the profile of mediators MIF, SCF, MCP-1, HGF, SCGF-beta, IP-10, IL-18, and IFN-gamma is an independent outcome predictor. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | A H7N9 VIRUS ; DISEASE CLASSIFICATION-SYSTEM ; ACUTE RESPIRATORY SYNDROME ; ACUTE LUNG INJURY ; HUMAN INFECTIONS ; H1N1 VIRUS ; APACHE-II ; EXPRESSION ; SEVERITY ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355606400001 |
| 源URL | [http://124.16.173.210/handle/834782/1481]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Zhejiang Univ, Coll Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China 2.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China 4.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China 5.Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China 6.Hangzhou Ctr Dis Control & Prevent, Hangzhou 310021, Zhejiang, Peoples R China 7.Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China 8.Fudan Univ, Childrens Hosp, Shanghai 201102, Peoples R China 9.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccine, Tianjin 300308, Peoples R China 10.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jing,Huang, Fengming,Liu, Jun,et al. The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Guo, Jing.,Huang, Fengming.,Liu, Jun.,Chen, Yu.,Wang, Wei.,...&Jiang, Chengyu.(2015).The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes.SCIENTIFIC REPORTS,5. |
| MLA | Guo, Jing,et al."The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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