Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice
文献类型：期刊论文
| 作者 | Bi, Yuhai1,2,5; Xiao, Haixia3,5; Chen, Quanjiao4,5; Wu, Yan; Fu, Lifeng; Quan, Chuansong6; Wong, Gary; Liu, Jun5,6; Haywood, Joel1; Liu, Yingxia2 |
| 刊名 | JOURNAL OF VIROLOGY
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 90期号:4页码:2142-2149 |
| 英文摘要 | The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19-to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Virology |
| 研究领域[WOS] | Virology |
| 关键词[WOS] | INFLUENZA-A VIRUS ; HEMAGGLUTININ CLEAVAGE ; FUNCTIONAL BALANCE ; PATHOGENICITY ; CHICKENS ; TRANSMISSION ; REPLICATION ; EMERGENCE ; FERRETS ; HUMANS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369152700040 |
| 源URL | [http://124.16.173.210/handle/834782/1542]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 2.Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Beijing 100864, Hubei, Peoples R China 5.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China 6.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China 7.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Peoples R China 8.Chinese Acad Sci, RNIH, Beijing Inst Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bi, Yuhai,Xiao, Haixia,Chen, Quanjiao,et al. Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice[J]. JOURNAL OF VIROLOGY,2016,90(4):2142-2149. |
| APA | Bi, Yuhai.,Xiao, Haixia.,Chen, Quanjiao.,Wu, Yan.,Fu, Lifeng.,...&Gao, George F..(2016).Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice.JOURNAL OF VIROLOGY,90(4),2142-2149. |
| MLA | Bi, Yuhai,et al."Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice".JOURNAL OF VIROLOGY 90.4(2016):2142-2149. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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