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Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine

文献类型：期刊论文

作者Hishiike, Takashi1; Ogawa, Masahiro1; Hayakawa, Shigeru1; Nakajima, Daichi1; O'Charoen, Siwaporn1; Ooshima, Hisaka2; Sun, Yuanxia1,3
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2013-07-31
卷号61期号:30页码:7381-7386
关键词Caco-2 rare sugar GLUT5 GLUT2
英文摘要D-Psicose (Psi), the C3-epimer of D-fructose (Fru), is a noncalorie sugar with a lower glycemic response. The trans-cellular pathway of Psi in human enterocytes was investigated using a Caco-2 cell monolayer. The permeation rate of Psi across the monolayer was not affected by the addition of phlorizin, an inhibitor of sugar transporter SGLT1, whereas it was accelerated by treatment with forskolin, a GLUT5-gene inducer, clearly showing that GLUT5 is involved in the transport of Psi. The permeability of Psi was suppressed in the presence of D-glucose (Glc) and Fru, suggesting that the three monosaccharides are transported via the same transporter. Since GLUT2, the predominant sugar transporter on the basolateral membrane of enterocytes, mediates the transport of Glc and Fru, Psi might be mediated by GLUT2. The present study shows that Psi is incorporated from the intestinal lumen into enterocytes via GLUT5 and is released to the lamina propria via GLUT2.
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]D-TAGATOSE 3-EPIMERASE ; D-ALLOSE ; GLUCOSE-TRANSPORTER ; CACO-2 CELLS ; RATS ; FRUCTOSE ; SYSTEM ; PHLORHIZIN ; SUPPRESSES ; HEXOSE
收录类别SCI
语种英语
WOS记录号WOS:000322752700027
源URL[http://124.16.173.210/handle/834782/1275]  
专题天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文
作者单位1.Kagawa Univ, Fac Agr, Dept Appl Biol Sci, Miki, Kagawa 7610795, Japan
2.Kagawa Prefectural Ind Technol Ctr, Fermentat & Food Res Branch, Shodoshima, Kagawa 7614421, Japan
3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China
推荐引用方式
GB/T 7714		 Hishiike, Takashi,Ogawa, Masahiro,Hayakawa, Shigeru,et al. Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2013,61(30):7381-7386.
APA Hishiike, Takashi.,Ogawa, Masahiro.,Hayakawa, Shigeru.,Nakajima, Daichi.,O'Charoen, Siwaporn.,...&Sun, Yuanxia.(2013).Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,61(30),7381-7386.
MLA Hishiike, Takashi,et al."Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 61.30(2013):7381-7386.

入库方式： OAI收割

来源：天津工业生物技术研究所

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