Structural characterization and immunostimulating activity of a levan-type fructan from Curcuma kwangsiensis
文献类型：期刊论文
| 作者 | Dong, Cai-Xia1; Zhang, Li-Jiao2; Xu, Rong3; Zhang, Gong1; Zhou, Ying-Biao2; Han, Xiao-Qiang4; Zhang, Ying2; Sun, Yuan-Xia2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 77页码:99-104 |
| 关键词 | Curcuma kwangsiensis Levan-type fructan Immunostimulating activity |
| 英文摘要 | A fructan designated as CKNP with apparent molecular weight of 5.3 kD was isolated from the hot water extract of Curcuma kwangsiensis through a combination of ion-exchange chromatography on DEAE 650 M and gel filtration on Superdex G-200. CKNP was characterized by chemical derivatization as well as HPLC, GC, and GC-MS technologies. Structural studies revealed that CKNP is composed predominately of fructose (96.8%) and a small amount of glucose (3.2%) with a degree of polymerization (DP) of 30-31. It was deduced to be a levan-type fructan containing a backbone composed of (2 -> 6)-linked beta-D-Fruf residues and single beta-D-Fruf residues as side chains branched at the O-1 position along the backbone. Preliminary in vitro bioactive tests on RAW 264.7 murine macrophage cells revealed that the levan-type fructan from C. kwangsiensis shows significant immunostimulating activity based on its ability to stimulate macrophage proliferation and enhance phagocytosis. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | POLYSACCHARIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355713900012 |
| 源URL | [http://124.16.173.210/handle/834782/1492]  |
| 专题 | 天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文 |
| 作者单位 | 1.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 3.Quanzhou Med Coll, Dept Pharm, Quanzhou 362011, Peoples R China 4.Chinese Univ Hong Kong, Inst Chinese Med, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Cai-Xia,Zhang, Li-Jiao,Xu, Rong,et al. Structural characterization and immunostimulating activity of a levan-type fructan from Curcuma kwangsiensis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015,77:99-104. |
| APA | Dong, Cai-Xia.,Zhang, Li-Jiao.,Xu, Rong.,Zhang, Gong.,Zhou, Ying-Biao.,...&Sun, Yuan-Xia.(2015).Structural characterization and immunostimulating activity of a levan-type fructan from Curcuma kwangsiensis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,77,99-104. |
| MLA | Dong, Cai-Xia,et al."Structural characterization and immunostimulating activity of a levan-type fructan from Curcuma kwangsiensis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 77(2015):99-104. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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