Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei
文献类型：期刊论文
| 作者 | He, Ronglin1; Ma, Lijuan2; Li, Chen1; Jia, Wendi1; Li, Demao1; Zhang, Dongyuan1; Chen, Shulin1 |
| 刊名 | ENZYME AND MICROBIAL TECHNOLOGY
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 67页码:17-26 |
| 关键词 | Cellulase regulation pH Transcription factors Trichoderma reesei Trpac1 |
| 英文摘要 | Fungi grow over a relatively wide pH range and adapt to extracellular pH through a genetic regulatory system mediated by a key component PacC, which is a pH transcription regulator. The cellulase production of the filamentous fungi Trichoderma reesei is sensitive to ambient pH. To investigate the connection between cellulase expression regulation and ambient pH, an ortholog of Aspergillus nidulans pacC, Trpac1, was identified and functionally characterized using a target gene deletion strategy. Deleting Trpac1 dramatically increased the cellulase production and the transcription levels of the major cellulase genes at neutral pH, which suggested Trpac1 is involved in the regulation of cellulase production. It was further observed that the expression levels of transcription factors xyr1 and ace2 also increased in the Delta Trpac1 mutant at neutral pH. In addition, the Delta Trpac1 mutant exhibited conidiation defects under neutral and alkaline pH. These results implied that Trpac1 in involved in growth and development process and cellulase gene expression in T. reesei. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | HYPOCREA-JECORINA ; FUSARIUM-OXYSPORUM ; XYLANASE GENES ; ENZYME-SYSTEM ; FACTOR PACC ; AMBIENT PH ; VIRULENCE ; FUNGUS ; PATHOGENESIS ; HOMOLOG |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345475800003 |
| 源URL | [http://124.16.173.210/handle/834782/1357]  |
| 专题 | 天津工业生物技术研究所_工业生物系统工程实验室 陈树林_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China 2.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin Econ & Technol Dev Area TEDA, Tianjin 300457, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Ronglin,Ma, Lijuan,Li, Chen,et al. Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei[J]. ENZYME AND MICROBIAL TECHNOLOGY,2014,67:17-26. |
| APA | He, Ronglin.,Ma, Lijuan.,Li, Chen.,Jia, Wendi.,Li, Demao.,...&Chen, Shulin.(2014).Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei.ENZYME AND MICROBIAL TECHNOLOGY,67,17-26. |
| MLA | He, Ronglin,et al."Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei".ENZYME AND MICROBIAL TECHNOLOGY 67(2014):17-26. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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