The ComP-ComA Quorum System Is Essential For "Trojan horse" Like Pathogenesis in Bacillus nematocida
文献类型：期刊论文
| 作者 | Deng, Xidan1,2,3; Tian, Yunxia1,2; Niu, Qiuhong4; Xu, Xiao'e1,2; Shi, Hui1,2; Zhang, Hanbo1,2; Liang, Lianming1,2; Zhang, Keqin1,2; Huang, Xiaowei1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-10-09 |
| 卷号 | 8期号:10 |
| 英文摘要 | Bacillus nematocida B16 has been shown to use "Trojan horse" mechanism in pathogenesis that has characteristics of "social" behavior. The ComP-ComA system, a conserved quorum sensing system in the genus Bacillus, functions in many physiological processes including competence development, lipopeptide antibiotic surfactin production, degradative enzyme production and even some unknown functions. Here we investigated the requirement of ComP-ComA system in B. nematocida B16 for its pathogenicity against nematodes. The Delta comP mutant displayed deficiencies in attracting and killing nematodes, due to the absence of attractive signal molecules and the decreased expressions of virulence factors, respectively. Contrarily, a complemented comP mutant at least partially resumed its pathogenicity. Our data from transcriptional analysis further confirmed that this signaling system directly or indirectly regulated the expressions of two major virulence proteases in the infection of B. nematocida B16. Bioinformatics analyses from comparative genomics also suggested that the potential target genes of transcription factor ComA were involved in the processes such as the synthesis of attractants, production of extracellular degradative enzymes and sortase, secondary metabolites biosynthesis, regulation of transcription factors, mobility, as well as transporters, most of which were different from a saprophytic relative B. subtilis 168. Therefore, our investigation firstly revealed that the participation and necessity of ComP-ComA signaling system in bacterial pathogenesis. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | GRAM-POSITIVE BACTERIA ; TO-CELL COMMUNICATION ; PSEUDOMONAS-AERUGINOSA ; VIRULENCE REGULATION ; NEGATIVE BACTERIA ; GENOME ANALYSIS ; SENSING SYSTEM ; CEREUS GROUP ; SUBTILIS ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000325810900105 |
| 源URL | [http://124.16.173.210/handle/834782/1246]  |
| 专题 | 天津工业生物技术研究所_合成基因组学实验室 田敬东 _期刊论文 |
| 作者单位 | 1.Yunnan Univ, Lab Conservat & Utilizat Bioresources, Minist Educ, Kunming, Yunnan, Peoples R China 2.Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 4.Nanyang Normal Univ, Sch Life Sci & Technol, Nanyang, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xidan,Tian, Yunxia,Niu, Qiuhong,et al. The ComP-ComA Quorum System Is Essential For "Trojan horse" Like Pathogenesis in Bacillus nematocida[J]. PLOS ONE,2013,8(10). |
| APA | Deng, Xidan.,Tian, Yunxia.,Niu, Qiuhong.,Xu, Xiao'e.,Shi, Hui.,...&Huang, Xiaowei.(2013).The ComP-ComA Quorum System Is Essential For "Trojan horse" Like Pathogenesis in Bacillus nematocida.PLOS ONE,8(10). |
| MLA | Deng, Xidan,et al."The ComP-ComA Quorum System Is Essential For "Trojan horse" Like Pathogenesis in Bacillus nematocida".PLOS ONE 8.10(2013). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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