DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related
文献类型：期刊论文
| 作者 | Lu, Na1,2; Hu, Yongfei1,2; Zhu, Liying3; Yang, Xi1,2; Yin, Yeshi3; Lei, Fang4; Zhu, Yongliang5; Du, Qin5; Wang, Xin3; Meng, Zhiqi3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014-03-12 |
| 卷号 | 4 |
| 英文摘要 | The human gut is a reservoir for antibiotic resistance genes. In this report, we used a DNA microarray chip covering 369 resistance types to investigate the relationship between antibiotic resistance-gene diversity and human age. Metagenomic DNA from fecal samples from 124 healthy volunteers of four different age groups (pre-school-aged children (CH), school-aged children (SC), high school students (HSS) and adults (AD)) were hybridized to the microarray chip. The results showed that 80 different gene types were recovered from the gut microbiota of the 124 individuals: 25 from CH, 37 from SC, 58 from HSS and 72 from AD. Further analysis indicated that the antibiotic resistance genes in the CH, SC and AD groups clustered independently, whereas the gene types in the HSS group were more divergent. Our results indicated that antibiotic resistance genes in the human gut microbiota accumulate from childhood to adulthood and become more complex with age. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ANTIMICROBIAL RESISTANCE ; DETERMINANTS ; BACTERIA ; DATABASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332620600001 |
| 源URL | [http://124.16.173.210/handle/834782/1406]  |
| 专题 | 天津工业生物技术研究所_基因工程与微生物应用技术研究组 宋恢_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Beijing Key Lab Microbial Drug Resistance & Resi, Beijing, Peoples R China 3.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R China 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 5.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Na,Hu, Yongfei,Zhu, Liying,et al. DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Lu, Na.,Hu, Yongfei.,Zhu, Liying.,Yang, Xi.,Yin, Yeshi.,...&Zhu, Baoli.(2014).DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related.SCIENTIFIC REPORTS,4. |
| MLA | Lu, Na,et al."DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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