Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies
文献类型：期刊论文
| 作者 | Liu, Guiyou1,2; Jiang, Yongshuai3; Chen, Xiaoguang4; Zhang, Ruijie3; Ma, Guoda1; Feng, Rennan5; Zhang, Liangcai6; Liao, Mingzhi3; Miao, Yingbo3; Chen, Zugen7 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-10-18 |
| 卷号 | 8期号:10 |
| 英文摘要 | Growing evidence from epidemiological studies indicates the association between rheumatoid arthritis (RA) and measles. However, the exact mechanism for this association is still unclear now. We consider that the strong association between both diseases may be caused by shared genetic pathways. We performed a pathway analysis of large-scale RA genome-wide association studies (GWAS) dataset with 5,539 cases and 20,169 controls of European descent. Meanwhile, we evaluated our findings using previously identified RA loci, protein-protein interaction network and previous results from pathway analysis of RA and other autoimmune diseases GWAS. We confirmed four pathways including Cytokine-cytokine receptor interaction, Jak-STAT signaling, T cell receptor signaling and Cell adhesion molecules. Meanwhile, we highlighted for the first time the involvement of Measles and Intestinal immune network for IgA production pathways in RA. Our results may explain the strong association between RA and measles, which may be caused by the shared genetic pathway. We believe that our results will be helpful for future genetic studies in RA pathogenesis and may significantly assist in the development of therapeutic strategies. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | COLLAGEN-INDUCED ARTHRITIS ; JAPANESE POPULATION ; ENRICHMENT ANALYSIS ; MULTIPLE-SCLEROSIS ; RISK LOCUS ; GENE ; SUSCEPTIBILITY ; DISEASES ; EXPRESSION ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326029300005 |
| 源URL | [http://124.16.173.210/handle/834782/1233]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Guangdong Med Coll, Inst Neurol, Zhanjiang, Peoples R China 2.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 3.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 4.Chinese Acad Agr Sci, Sweetpotato Res Inst, Key Lab Sweetpotato Biol & Genet Breeding, Xuzhou, Jiangsu, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Div Quantitat Sci, Houston, TX 77030 USA 7.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA 8.Guangdong Med Coll, Affiliated Hosp, Dept Orthoped Surg, Zhanjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Guiyou,Jiang, Yongshuai,Chen, Xiaoguang,et al. Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies[J]. PLOS ONE,2013,8(10). |
| APA | Liu, Guiyou.,Jiang, Yongshuai.,Chen, Xiaoguang.,Zhang, Ruijie.,Ma, Guoda.,...&Li, Keshen.(2013).Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies.PLOS ONE,8(10). |
| MLA | Liu, Guiyou,et al."Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies".PLOS ONE 8.10(2013). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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