PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population
文献类型：期刊论文
| 作者 | Liu, Guiyou1,2; Zhang, Shuyan3; Cai, Zhiyou4; Ma, Guoda1; Zhang, Liangcai5; Jiang, Yongshuai5; Feng, Rennan6; Liao, Mingzhi5; Chen, Zugen7; Zhao, Bin4 |
| 刊名 | NEUROMOLECULAR MEDICINE
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 15期号:2页码:384-388 |
| 关键词 | Alzheimer's disease Genome-wide association studies PICALM gene rs3851179 polymorphism Caucasian Asian |
| 英文摘要 | PICALM gene rs3851179 polymorphism was reported to an Alzheimer's disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population. Four studies indicated no association between rs3851179 and AD in a Chinese population and one study reported weak association in a Japanese population. We consider that the failure to replicate the significant association between rs3851179 and AD may be caused by at least two reasons. The first reason may be the genetic heterogeneity in AD among different populations, and the second may be the relatively small sample size compared with large-scale GWAS in Caucasian ancestry. In order to confirm this view, in this research, we first evaluated the genetic heterogeneity of rs3851179 polymorphism in Caucasian and Asian populations. We then investigated rs3851179 polymorphism in an Asian population by a pooled analysis method and a meta-analysis method. We did not observe significant genetic heterogeneity of rs3851179 in the Caucasian and Asian populations. Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. We believe that our findings will be very useful for future genetic studies in AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | COMMON VARIANTS ; ASSOCIATION ; LOCI ; CLU ; CHINESE ; CD2AP ; EPHA1 ; CD33 ; CR-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318844500013 |
| 源URL | [http://124.16.173.210/handle/834782/1279]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Beijing, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin 150001, Peoples R China 4.Guangdong Med Coll, Affiliated Hosp, Key Lab Aging Related Cardiocerebral Dis Guangdon, Zhanjiang 524001, Peoples R China 5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 6.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 7.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA |
| 推荐引用方式 GB/T 7714 | Liu, Guiyou,Zhang, Shuyan,Cai, Zhiyou,et al. PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population[J]. NEUROMOLECULAR MEDICINE,2013,15(2):384-388. |
| APA | Liu, Guiyou.,Zhang, Shuyan.,Cai, Zhiyou.,Ma, Guoda.,Zhang, Liangcai.,...&Li, Keshen.(2013).PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population.NEUROMOLECULAR MEDICINE,15(2),384-388. |
| MLA | Liu, Guiyou,et al."PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".NEUROMOLECULAR MEDICINE 15.2(2013):384-388. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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