System Analysis of LWDH Related Genes Based on Text Mining in Biological Networks
文献类型：期刊论文
| 作者 | Liao, Mingzhi1; Miao, Yingbo2; Zhang, Liangcai3,4; Wang, Yang1; Feng, Rennan3,5; Yang, Lei3; Zhang, Shihua6; Jiang, Yongshuai3; Liu, Guiyou3,7 |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2014 |
| 英文摘要 | Liuwei-dihuang (LWDH) is widely used in traditional Chinese medicine (TCM), but its molecular mechanism about gene interactions is unclear. LWDH genes were extracted from the existing literatures based on text mining technology. To simulate the complex molecular interactions that occur in the whole body, protein-protein interaction networks (PPINs) were constructed and the topological properties of LWDH genes were analyzed. LWDH genes have higher centrality properties and may play important roles in the complex biological network environment. It was also found that the distances within LWDH genes are smaller than expected, which means that the communication of LWDH genes during the biological process is rapid and effectual. At last, a comprehensive network of LWDH genes, including the related drugs and regulatory pathways at both the transcriptional and posttranscriptional levels, was constructed and analyzed. The biological network analysis strategy used in this study may be helpful for the understanding of molecular mechanism of TCM. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 关键词[WOS] | TRADITIONAL CHINESE MEDICINE ; PROTEIN INTERACTION NETWORK ; TOPOLOGICAL PROPERTIES ; DRUG DISCOVERY ; TARGETS ; PHARMACOLOGY ; THERAPEUTICS ; FORMULA ; DISEASE ; UPDATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344280500001 |
| 源URL | [http://124.16.173.210/handle/834782/1371]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Northwest A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China 2.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China 3.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150081, Peoples R China 4.Rice Univ, Dept Stat, Houston, TX 77005 USA 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Peoples R China 6.Anhui Agr Univ, Coll Life Sci, Hefei 230036, Peoples R China 7.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Mingzhi,Miao, Yingbo,Zhang, Liangcai,et al. System Analysis of LWDH Related Genes Based on Text Mining in Biological Networks[J]. BIOMED RESEARCH INTERNATIONAL,2014. |
| APA | Liao, Mingzhi.,Miao, Yingbo.,Zhang, Liangcai.,Wang, Yang.,Feng, Rennan.,...&Liu, Guiyou.(2014).System Analysis of LWDH Related Genes Based on Text Mining in Biological Networks.BIOMED RESEARCH INTERNATIONAL. |
| MLA | Liao, Mingzhi,et al."System Analysis of LWDH Related Genes Based on Text Mining in Biological Networks".BIOMED RESEARCH INTERNATIONAL (2014). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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