Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks
文献类型：期刊论文
| 作者 | Li, Leijie1; Zhang, Liangcai2,3; Liu, Guiyou2,4; Feng, Rennan2,5; Jiang, Yongshuai2; Yang, Lei2; Zhang, Shihua6; Liao, Mingzhi1; Hua, Jinlian7 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014-08-29 |
| 卷号 | 9期号:8 |
| 英文摘要 | The molecular mechanism that maintains the pluripotency of embryonic stem cells (ESCs) is not well understood but may be reflected in complex biological networks. However, there have been few studies on the effects of transcriptional and post-transcriptional regulation during the development of ESCs from the perspective of computational systems biology. In this study, we analyzed the topological properties of the "core'' pluripotency transcription factors (TFs) OCT4, SOX2 and NANOG in protein-protein interaction networks (PPINs). Further, we identified synergistic interactions between these TFs and microRNAs (miRNAs) in PPINs during ESC development. Results show that there were significant differences in centrality characters between TF-targets and non-TF-targets in PPINs. We also found that there was consistent regulation of multiple "core'' pluripotency TFs. Based on the analysis of shortest path length, we found that the module properties were not only within the targets regulated by common or multiple "core'' pluripotency TFs but also between the groups of targets regulated by different TFs. Finally, we identified synergistic regulation of these TFs and miRNAs. In summary, the synergistic effects of "core'' pluripotency TFs and miRNAs were analyzed using computational methods in both human and mouse PPINs. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; HUMAN SOMATIC-CELLS ; BIOLOGICAL NETWORKS ; SELF-RENEWAL ; MOUSE ; NANOG ; OCT4 ; CIRCUITRY ; GENES ; VISUALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341127500034 |
| 源URL | [http://124.16.173.210/handle/834782/1395]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 2.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 3.Rice Univ, Dept Stat, Houston, TX 77251 USA 4.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Anhui Agr Univ, Sch Sci, Dept Biostat, Hefei, Peoples R China 7.Northwest A&F Univ, Shaanxi Ctr Stem Cells Engn & Technol, Coll Vet Med, Yangling, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Leijie,Zhang, Liangcai,Liu, Guiyou,et al. Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks[J]. PLOS ONE,2014,9(8). |
| APA | Li, Leijie.,Zhang, Liangcai.,Liu, Guiyou.,Feng, Rennan.,Jiang, Yongshuai.,...&Hua, Jinlian.(2014).Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks.PLOS ONE,9(8). |
| MLA | Li, Leijie,et al."Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks".PLOS ONE 9.8(2014). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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