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The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer's Disease in Caucasian and Asian Populations

文献类型：期刊论文

作者Liu, Guiyou1,2; Wang, Haiyang3; Liu, Jiafeng4; Li, Jingbo3; Li, Hali3; Ma, Guoda1; Jiang, Yongshuai5; Chen, Zugen6; Zhao, Bin1,7; Li, Keshen1
刊名NEUROMOLECULAR MEDICINE
出版日期2014-03-01
卷号16期号:1页码:52-60
关键词Alzheimer's disease Genomewide association study CLU rs11136000 polymorphism Asian population Caucasian ancestry
英文摘要Large-scale genomewide association studies have reported that the CLU rs11136000 polymorphism is significantly associated with Alzheimer's disease (AD) in people of Caucasian ancestry. Recently, this association was investigated in Asian populations (Chinese, Japanese, and Korean). However, these studies reported either a weak association or no association between the rs11136000 polymorphism and AD. We believe that this discrepancy may be caused by the relatively small sample size of the previous studies and the genetic heterogeneity of the rs11136000 polymorphism in AD among different populations. For this study, we searched the PubMed and AlzGene databases. We selected 18 independent studies (6 studies of Asian populations and 12 of populations of Caucasian ancestry) that evaluated the association between the rs11136000 polymorphism and AD using a case-control experimental design. We evaluated the genetic heterogeneity of the rs11136000 polymorphism in Caucasian and Asian populations. We then investigated the rs11136000 polymorphism by a meta-analysis in Asian populations using allele, dominant, and recessive models. We identified a significant association between rs11136000 and AD with the allele model (P = 2.00 x 10(-4)) and the dominant model (P = 5.00 x 10(-3)). Meanwhile, a similar genetic risk of the rs11136000 polymorphism in AD was observed in Asian and Caucasian populations. Further meta-analysis in pooled Asian and Caucasian populations indicated a more significant association with the allele (P = 8.30 x 10(-24)), dominant (P = 4.46 x 10(-17)), and recessive (P = 3.92 x 10(-12)) models. Collectively, our findings from this meta-analysis indicate that the effect of the CLU rs11136000 polymorphism on AD risk in Asian cohorts (Chinese, Japanese, and Korean) is consistent with the protective effect observed in Caucasian AD cohorts.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GENOME-WIDE ASSOCIATION ; IDENTIFIES VARIANTS ; COMMON VARIANTS ; RISK VARIANT ; CD2AP ; EPHA1 ; CD33 ; CR-1
收录类别SCI
语种英语
WOS记录号WOS:000331101900006
源URL[http://124.16.173.210/handle/834782/1413]  
专题天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文
作者单位1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China
2.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Beijing, Peoples R China
3.Harbin Med Univ, Dept Vasc Surg Gen Surg, Affiliated Hosp 1, Harbin 150001, Peoples R China
4.First Hosp Harbin, Dept Neurol, Harbin, Heilongjiang, Peoples R China
5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China
6.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA
7.Guangdong Med Coll, Affiliated Hosp, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Guiyou,Wang, Haiyang,Liu, Jiafeng,et al. The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer's Disease in Caucasian and Asian Populations[J]. NEUROMOLECULAR MEDICINE,2014,16(1):52-60.
APA Liu, Guiyou.,Wang, Haiyang.,Liu, Jiafeng.,Li, Jingbo.,Li, Hali.,...&Li, Keshen.(2014).The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer's Disease in Caucasian and Asian Populations.NEUROMOLECULAR MEDICINE,16(1),52-60.
MLA Liu, Guiyou,et al."The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer's Disease in Caucasian and Asian Populations".NEUROMOLECULAR MEDICINE 16.1(2014):52-60.

入库方式： OAI收割

来源：天津工业生物技术研究所

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