An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease
文献类型：期刊论文
| 作者 | Shen, Ning1; Chen, Bin2; Jiang, Yongshuai3; Feng, Rennan4; Liao, Mingzhi3; Zhang, Liangcai5; Li, Fujun6; Ma, Guoda7; Chen, Zugen8; Zhao, Bin9 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 51期号:3页码:1017-1023 |
| 关键词 | Alzheimer's disease Complement receptor 1 Polymorphism |
| 英文摘要 | The complement receptor 1 (CR1) rs6656401 polymorphism was first identified to be associated with Alzheimer's disease (AD) in European ancestry. However, the following studies reported weak or no significant association in Chinese, Japanese, Korean, African-American, Polish, and Canadian populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous genome-wide association studies (GWAS) in European ancestry or the genetic heterogeneity of the rs6656401 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from previous 24 studies (N = 85,939, 30,100 cases and 55,839 controls) by searching the PubMed, AlzGene, and Google Scholar databases. Using additive model, we did not identify significant heterogeneity among the 24 studies. We observed significant association between the rs6656401 polymorphism and AD in pooled populations (P = 1.82E-26, odds ratio (OR) = 1.18, 95 % confidence interval (CI) 1.15-1.22). In subgroup analysis, we identified significant results in East Asian population with P = 5.00E-04, OR = 1.31, 95 % CI 1.13-1.52. To our knowledge, this is the first meta-analysis to investigate the association between rs6656401 polymorphism and AD in East Asian, African-American, Canadian, and European populations. Our analysis further supports previous findings that the CR1 rs6656401 polymorphism contributes to AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; POPULATION ; VARIANTS ; CLU ; METAANALYSIS ; CONTRIBUTES ; PICALM ; GENES ; RISK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354625100015 |
| 源URL | [http://124.16.173.210/handle/834782/1486]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Heilongjiang Univ Chinese Med, Sch Basic Med Sci, Dept Physiol, Harbin, Peoples R China 2.Beijing PLA, Dept Endocrinol & Metab, Mil Gen Hosp, Beijing, Peoples R China 3.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 4.Harbin Med Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Harbin, Peoples R China 5.Rice Univ, Dept Stat, Houston, TX 77251 USA 6.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China 7.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 8.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA 9.Guangdong Med Coll, Affiliated Hosp, Key Lab Aging Related Cardiocerebral Dis Guangdon, Zhanjiang 524001, Peoples R China 10.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Ning,Chen, Bin,Jiang, Yongshuai,et al. An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease[J]. MOLECULAR NEUROBIOLOGY,2015,51(3):1017-1023. |
| APA | Shen, Ning.,Chen, Bin.,Jiang, Yongshuai.,Feng, Rennan.,Liao, Mingzhi.,...&Liu, Guiyou.(2015).An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease.MOLECULAR NEUROBIOLOGY,51(3),1017-1023. |
| MLA | Shen, Ning,et al."An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease".MOLECULAR NEUROBIOLOGY 51.3(2015):1017-1023. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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