Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility
文献类型：期刊论文
| 作者 | Chen, Guangyuan1; Fu, Xiuhua2; Wang, Guangyu3; Liu, Guiyou4; Bai, Xiuping5 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 16期号:5页码:11678-11688 |
| 关键词 | myocardial infarction rs10757278 meta-analysis |
| 英文摘要 | Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 x 10(-22), odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.22-1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 x 10(-53), after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; CORONARY-ARTERY-DISEASE ; SINGLE NUCLEOTIDE POLYMORPHISMS ; HAN CHINESE ; FUNNEL PLOTS ; 4 SNPS ; POPULATION ; RISK ; METAANALYSES ; BIAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356241400147 |
| 源URL | [http://124.16.173.210/handle/834782/1497]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.First Hosp Harbin, Harbin 150070, Heilongjiang, Peoples R China 2.Second Peoples Hosp Mudanjiang, Dept Internal Circulat, Mudanjiang 157013, Heilongjiang, Peoples R China 3.Harbin Med Univ, Dept Gastrointestinal Med Oncol, Affiliated Tumor Hosp, Harbin 150081, Heilongjiang, Peoples R China 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300308, Peoples R China 5.Harbin Med Univ, Dept Cardiol, Affiliated Hosp 4, Harbin 150001, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guangyuan,Fu, Xiuhua,Wang, Guangyu,et al. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(5):11678-11688. |
| APA | Chen, Guangyuan,Fu, Xiuhua,Wang, Guangyu,Liu, Guiyou,&Bai, Xiuping.(2015).Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(5),11678-11688. |
| MLA | Chen, Guangyuan,et al."Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.5(2015):11678-11688. |
入库方式： OAI收割
来源：天津工业生物技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。