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  3. 基因组分析实验室 陈祖耕
  4. 期刊论文
CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations

文献类型：期刊论文

作者Li, Xingwang1,2; Shen, Ning3; Zhang, Shuyan4; Liu, Jiafeng5; Jiang, Qinghua6; Liao, Mingzhi7; Feng, Rennan8; Zhang, Liangcai9; Wang, Guangyu10; Ma, Guoda11
刊名MOLECULAR NEUROBIOLOGY
出版日期2015-08-01
卷号52期号:1页码:414-421
关键词CD33 rs3865444 polymorphism Alzheimer's disease European North American Asian
英文摘要The CD33 rs3865444 polymorphism was first identified to be associated with Alzheimer's disease (AD) in European population. However, the following studies reported weak or no significant association in Chinese, Japanese, Korean, American, and Canadian populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous GWAS in European ancestry or the genetic heterogeneity of the rs3865444 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from previous 27 studies (N = 86,759; 31,106 cases and 55,653 controls) by searching the PubMed, AlzGene, and Google Scholar databases. We identified significant heterogeneity and observed no significant association between the rs3865444 polymorphism and AD in pooled populations (P = 0.264, odds ratio (OR) = 0.97, 95 % confidence interval (CI) 0.93-1.02). In subgroup analysis, we identified significant heterogeneity only in East Asian population and observed no significant association between the rs3865444 polymorphism and AD. We further identified significant heterogeneity and observed significant association between the rs3865444 polymorphism and AD in Chinese population. We identified no significant heterogeneity and significant association in North American and European populations. Collectively, our analysis shows that the CD33 rs3865444 polymorphism is associated with AD susceptibility in Chinese, European, and North American populations. We believe that our findings will be very useful for future genetic studies on AD.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; EPHA1 ; CD2AP ; LOCI
收录类别SCI
语种英语
WOS记录号WOS:000358341600037
源URL[http://124.16.173.210/handle/834782/1502]  
专题天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文
作者单位1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Zhejiang, Peoples R China
2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China
3.Heilongjiang Univ Chinese Med, Sch Basic Med Sci, Dept Physiol, Harbin, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin, Peoples R China
5.First Hosp Harbin, Dept Neurol, Harbin, Peoples R China
6.Harbin Inst Technol, Acad Fundamental & Interdisciplinary Sci, Harbin 150006, Heilongjiang, Peoples R China
7.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China
8.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China
9.Rice Univ, Dept Stat, Houston, TX 77251 USA
10.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gastrointestinal Med Oncol, Harbin, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xingwang,Shen, Ning,Zhang, Shuyan,et al. CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations[J]. MOLECULAR NEUROBIOLOGY,2015,52(1):414-421.
APA Li, Xingwang.,Shen, Ning.,Zhang, Shuyan.,Liu, Jiafeng.,Jiang, Qinghua.,...&Liu, Guiyou.(2015).CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations.MOLECULAR NEUROBIOLOGY,52(1),414-421.
MLA Li, Xingwang,et al."CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations".MOLECULAR NEUROBIOLOGY 52.1(2015):414-421.

入库方式： OAI收割

来源：天津工业生物技术研究所

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