The drug target genes show higher evolutionary conservation than non-target genes
文献类型：期刊论文
| 作者 | Lv, Wenhua1; Xu, Yongdeng1; Guo, Yiying1; Yu, Ziqi1; Feng, Guanglong2; Liu, Panpan1; Luan, Meiwei1; Zhu, Hongjie1; Liu, Guiyou3; Zhang, Mingming1 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2016-01-26 |
| 卷号 | 7期号:4页码:4961-4971 |
| 关键词 | drug target evolutionary conservation topological properties |
| 英文摘要 | Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing evolutionary features of drug targets from an overall level. Therefore, we conducted an analysis which aimed to investigate the evolutionary characteristics of drug target genes. We compared the evolutionary conservation between human drug target genes and non-target genes by combining both the evolutionary features and network topological properties in human protein-protein interaction network. The evolution rate, conservation score and the percentage of orthologous genes of 21 species were included in our study. Meanwhile, four topological features including the average shortest path length, betweenness centrality, clustering coefficient and degree were considered for comparison analysis. Then we got four results as following: compared with non-drug target genes, 1) drug target genes had lower evolutionary rates; 2) drug target genes had higher conservation scores; 3) drug target genes had higher percentages of orthologous genes and 4) drug target genes had a tighter network structure including higher degrees, betweenness centrality, clustering coefficients and lower average shortest path lengths. These results demonstrate that drug target genes are more evolutionarily conserved than non-drug target genes. We hope that our study will provide valuable information for other researchers who are interested in evolutionary conservation of drug targets. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology ; Cell Biology |
| 研究领域[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | PROTEIN DATABASE ; PRIORITIZATION ; IDENTIFICATION ; EXPRESSION ; PREDICTION ; NETWORKS ; REVEALS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369952400099 |
| 源URL | [http://124.16.173.210/handle/834782/1533]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 2, Dept Radiol, Harbin, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Wenhua,Xu, Yongdeng,Guo, Yiying,et al. The drug target genes show higher evolutionary conservation than non-target genes[J]. ONCOTARGET,2016,7(4):4961-4971. |
| APA | Lv, Wenhua.,Xu, Yongdeng.,Guo, Yiying.,Yu, Ziqi.,Feng, Guanglong.,...&Zhang, Ruijie.(2016).The drug target genes show higher evolutionary conservation than non-target genes.ONCOTARGET,7(4),4961-4971. |
| MLA | Lv, Wenhua,et al."The drug target genes show higher evolutionary conservation than non-target genes".ONCOTARGET 7.4(2016):4961-4971. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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