Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals
文献类型：期刊论文
| 作者 | Shang, Zhenwei1; Lv, Hongchao1; Zhang, Mingming1; Duan, Lian1; Wang, Situo2; Li, Jin1; Liu, Guiyou3; Zhang Ruijie1; Jiang, Yongshuai1 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015-12-15 |
| 卷号 | 6期号:40页码:42504-42514 |
| 关键词 | Alzheimer's disease haplotype association analysis Pathology Section |
| 英文摘要 | Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It is considered to be caused by variety of factors, such as age, environment and genetic factors. In order to identify the genetic affect factors of AD, we carried out a bioinformatic approach which combined genome-wide haplotype-based association study with gene prioritization. The raw SNP genotypes data was downloaded from GEO database (GSE33528). It contains 615 AD patients and 560 controls of Caribbean Hispanic individuals. Firstly, we identified the linkage disequilibrium (LD) haplotype blocks and performed genome-wide haplotype association study to screen significant haplotypes that were associated with AD. Then we mapped these significant haplotypes to genes and obtained candidate genes set for AD. At last, we prioritized AD candidate genes based on their similarity with 36 known AD genes, so as to identify AD related genes. The results showed that 141 haplotypes on 134 LD blocks were significantly associated with AD (P<1E-4), and these significant haplotypes were mapped to 132 AD candidate genes. After prioritizing these candidate genes, we found seven AD related genes: APOE, APOC1, TNFRSF1A, LRP1B, CDH1, TG and CASP7. Among these genes, APOE and APOC1 are known AD risk genes. For the other five genes TNFRSF1A, CDH1, CASP7, LRP1B and TG, this is the first genetic association study which showed the significant association between these five genes and AD susceptibility in Caribbean Hispanic individuals. We believe that our findings can provide a new perspective to understand the genetic affect factors of AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology ; Cell Biology |
| 研究领域[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | THYROGLOBULIN GENE ; PLASMA-LEVELS ; ONSET ; SUSCEPTIBILITY ; VARIANTS ; MICROGLIA ; NETWORK ; CLU ; HYPOTHYROIDISM ; PRIORITIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369907900009 |
| 源URL | [http://124.16.173.210/handle/834782/1535]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 2.Genome Sci Consortium, Genet Data Anal Grp, Harbin, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shang, Zhenwei,Lv, Hongchao,Zhang, Mingming,et al. Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals[J]. ONCOTARGET,2015,6(40):42504-42514. |
| APA | Shang, Zhenwei.,Lv, Hongchao.,Zhang, Mingming.,Duan, Lian.,Wang, Situo.,...&Jiang, Yongshuai.(2015).Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.ONCOTARGET,6(40),42504-42514. |
| MLA | Shang, Zhenwei,et al."Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals".ONCOTARGET 6.40(2015):42504-42514. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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