A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour
文献类型：期刊论文
| 作者 | Sharp, Gemma C.1; Ma, Hongwu2,3; Saunders, Philippa T. K.1; Norman, Jane E.1,4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-07-30 |
| 卷号 | 8期号:7 |
| 英文摘要 | Preterm birth is the single biggest cause of significant neonatal morbidity and mortality, and the incidence is rising. Development of new therapies to treat and prevent preterm labour is seriously hampered by incomplete understanding of the molecular mechanisms that initiate labour at term and preterm. Computational modelling provides a new opportunity to improve this understanding. It is a useful tool in (i) identifying gaps in knowledge and informing future research, and (ii) providing the basis for an in silico model of parturition in which novel drugs to prevent or treat preterm labour can be "tested". Despite their merits, computational models are rarely used to study the molecular events initiating labour. Here, we present the first attempt to generate a dynamic kinetic model that has relevance to the molecular mechanisms of preterm labour. Using published data, we model an important candidate signalling pathway in infection-induced preterm labour: that of lipopolysaccharide (LPS) -induced activation of Nuclear Factor kappa B. This is the first model of this pathway to explicitly include molecular interactions upstream of Nuclear Factor kappa B activation. We produced a formalised graphical depiction of the pathway and built a kinetic model based on ordinary differential equations. The kinetic model accurately reproduced published in vitro time course plots of Lipopolysaccharide-induced Nuclear Factor kappa B activation in mouse embryo fibroblasts. In this preliminary work we have provided proof of concept that it is possible to build computational models of signalling pathways that are relevant to the regulation of labour, and suggest that models that are validated with wet-lab experiments have the potential to greatly benefit the field. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | GENE-EXPRESSION ; BIRTH ; TOLL-LIKE-RECEPTOR-4 ; PROGESTERONE ; MYOMETRIUM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323114200061 |
| 源URL | [http://124.16.173.210/handle/834782/1232]  |
| 专题 | 天津工业生物技术研究所_计算生物设计 马洪武 _期刊论文 |
| 作者单位 | 1.Univ Edinburgh, Ctr Reprod Hlth, MRC, Edinburgh, Midlothian, Scotland 2.Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China 4.Univ Edinburgh, Tommys Ctr Maternal & Fetal Hlth, Edinburgh, Midlothian, Scotland |
| 推荐引用方式 GB/T 7714 | Sharp, Gemma C.,Ma, Hongwu,Saunders, Philippa T. K.,et al. A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour[J]. PLOS ONE,2013,8(7). |
| APA | Sharp, Gemma C.,Ma, Hongwu,Saunders, Philippa T. K.,&Norman, Jane E..(2013).A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour.PLOS ONE,8(7). |
| MLA | Sharp, Gemma C.,et al."A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour".PLOS ONE 8.7(2013). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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