Pleiotropy of the de novo-originated gene MDF1
文献类型：期刊论文
| 作者 | Li, Dan1; Yan, Zhihui2; Lu, Lina2; Jiang, Huifeng2; Wang, Wen1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014-12-02 |
| 卷号 | 4 |
| 英文摘要 | MDF1 is a young de novo-originated gene from a non-coding sequence in baker's yeast, S. cerevisiae, which can suppress mating and promote vegetative growth. Our previous experiments successfully demonstrated how Mdf1p binds to the key mating pathway determinant MAT alpha 2 to suppress mating. However, how Mdf1p promotes growth and fulfills the crosstalk between the yeast mating and growth pathways are still open questions. Thus, the adaptive significance of this new de novo gene remains speculative. Here, we show that Mdf1p shortens the lag phase of S. cerevisiae by physically interacting with SNF1, the governing factor for nonfermentable carbon source utilization, and thereby confers a selective advantage on yeasts through the rapid consumption of glucose in the early generational stage in rich medium. Therefore, MDF1 functions in two important molecular pathways, mating and fermentation, and mediates the crosstalk between reproduction and vegetative growth. Together, our results provide a comprehensive example of how a de novo-originated gene organizes new regulatory circuits and thereby confers a selective advantage on S. cerevisiae to allow exquisite adaptation to the changing environment. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | YEAST SACCHAROMYCES-CEREVISIAE ; ANTAGONISTIC PLEIOTROPY ; GLUCOSE REPRESSION ; PROTEIN-KINASE ; LAG PHASE ; EXPRESSION ; EVOLUTION ; MAINTENANCE ; DROSOPHILA ; COST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346259100008 |
| 源URL | [http://124.16.173.210/handle/834782/1372]  |
| 专题 | 天津工业生物技术研究所_酵母基因组工程课题组 江会锋_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Dan,Yan, Zhihui,Lu, Lina,et al. Pleiotropy of the de novo-originated gene MDF1[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Li, Dan,Yan, Zhihui,Lu, Lina,Jiang, Huifeng,&Wang, Wen.(2014).Pleiotropy of the de novo-originated gene MDF1.SCIENTIFIC REPORTS,4. |
| MLA | Li, Dan,et al."Pleiotropy of the de novo-originated gene MDF1".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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