Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom
文献类型：期刊论文
| 作者 | Li, Ning2; Li, Le3; Fang, Jin Cen3; Wong, Jack Ho1; Ng, Tzi Bun1; Jiang, Yun2; Wang, Chang Rong2; Zhang, Ni Ye2; Wen, Ting Yi4; Qu, Li Yuan2 |
| 刊名 | BIOSCIENCE REPORTS
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 32期号:3页码:221-228 |
| 关键词 | biological activity Pleurotus abalonus (abalone mushroom) polysaccharide-peptide complex structural characterization |
| 英文摘要 | A novel antioxidant polysaccharide-peptide complex LB-1b from the fruiting bodies of the edible abalone mushroom (Pleurotus abalonus) was purified and identified. The structural characteristic of LB-1b was identified by FTIR (Fourier-transform IR), C-13 NMR and H-1 NMR spectroscopy. LB-1b is a polysaccharide peptide complex that contains glucose, rhamnose, glucuronic acid and galactose in the molar ratio of 22.4:1:1.7:1.6 and the N-terminal sequence of its peptide moiety has also been determined. The N-terminal amino acid sequence of LB-1b, IPKERKEFQQAQHLK, showed some resemblance to antioxidant enzymes. LB-1b exhibited high antioxidant activity in erythrocyte haemolysis in vitro and the anti-proliferative activity towards hepatoma HepG2 cells and breast cancer MCF7 cells with an IC50 of 24 and 14 mu M respectively. LB-1b also demonstrated hypoglycaemic activity in drug-induced diabetic mice and anti-HIV-1 RT (reverse transcriptase) with an IC50 value of 12.5 mu M. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | BLOOD MONONUCLEAR-CELLS ; PLEUROTUS-OSTREATUS ; OYSTER MUSHROOM ; IMMUNOMODULATING CYTOKINES ; PROTEIN COMPLEXES ; GENE-EXPRESSION ; IN-VITRO ; ANTITUMOR ; GANODERMA ; CITRINOPILEATUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304892700002 |
| 源URL | [http://124.16.173.210/handle/834782/1328]  |
| 专题 | 天津工业生物技术研究所_酶工程实验室 马延和 _期刊论文 |
| 作者单位 | 1.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China 2.Nankai Univ, Coll Life Sci, Dept Microbiol, Tianjin 300071, Peoples R China 3.Chinese Acad Fishery Sci, Res Ctr Fishery Prod Standard & Qual, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, Key Lab Syst Microbial Biotechnol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Li, Le,Fang, Jin Cen,et al. Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom[J]. BIOSCIENCE REPORTS,2012,32(3):221-228. |
| APA | Li, Ning.,Li, Le.,Fang, Jin Cen.,Wong, Jack Ho.,Ng, Tzi Bun.,...&Liu, Fang.(2012).Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom.BIOSCIENCE REPORTS,32(3),221-228. |
| MLA | Li, Ning,et al."Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom".BIOSCIENCE REPORTS 32.3(2012):221-228. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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