Synthesis of optically active alpha-bromohydrins via reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase
文献类型：期刊论文
| 作者 | Ren, Jie; Dong, Wenyue; Yu, Benqing; Wu, Qiaqing; Zhu, Dunming |
| 刊名 | TETRAHEDRON-ASYMMETRY
 |
| 出版日期 | 2012-04-15 |
| 卷号 | 23期号:6-7页码:497-500 |
| 英文摘要 | Enantiomerically pure (S)-alpha-bromohydrins were prepared by the reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase from Candida magnolia with high yield and excellent enantiomeric excess when methyl tert-butyl ether was employed as the co-solvent, while avoiding the formation of by-products. This provides a new approach to access these chiral alpha-bromohydrins which are of pharmaceutical importance. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ALCOHOL-DEHYDROGENASE ; ASYMMETRIC REDUCTION ; ENZYMATIC-SYNTHESIS ; RECEPTOR AGONISTS ; CANDIDA MAGNOLIAE ; BUILDING-BLOCKS ; RESOLUTION ; DISCOVERY ; KETONES ; POTENT |
| 收录类别 | SCI ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000304643700013 |
| 源URL | [http://124.16.173.210/handle/834782/1306]  |
| 专题 | 天津工业生物技术研究所_生物催化与绿色化工 朱敦明_期刊论文 |
| 作者单位 | Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Jie,Dong, Wenyue,Yu, Benqing,et al. Synthesis of optically active alpha-bromohydrins via reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase[J]. TETRAHEDRON-ASYMMETRY,2012,23(6-7):497-500. |
| APA | Ren, Jie,Dong, Wenyue,Yu, Benqing,Wu, Qiaqing,&Zhu, Dunming.(2012).Synthesis of optically active alpha-bromohydrins via reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase.TETRAHEDRON-ASYMMETRY,23(6-7),497-500. |
| MLA | Ren, Jie,et al."Synthesis of optically active alpha-bromohydrins via reduction of alpha-bromoacetophenone analogues catalyzed by an isolated carbonyl reductase".TETRAHEDRON-ASYMMETRY 23.6-7(2012):497-500. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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