Synthesis of optically active dihydrocarveol via a stepwise or one-pot enzymatic reduction of (R)- and (S)-canrone
文献类型：期刊论文
| 作者 | Chen, Xi; Gao, Xiuzhen; Wu, Qiaqing; Zhu, Dunming |
| 刊名 | TETRAHEDRON-ASYMMETRY
 |
| 出版日期 | 2012-05-31 |
| 卷号 | 23期号:10页码:734-738 |
| 英文摘要 | A recombinant enoate reductase LacER from Lactobacillus casei catalyzed the reduction of (R)-carvone and (S)-carvone to give (2R,5R)-dihydrocarvone and (2R,5S)-dihydrocarvone with 99% and 86% de, respectively, which were further reduced to dihydrocarveols by a carbonyl reductase from Sporobolomyces salmonicolor SSCR or Candida magnolia CMCR. For (R)-carvone, (1S,2R,5R)-dihydrocarveol was produced as the sole product with >99% conversion, while (15,2R,5S)-dihydrocarveol was obtained as the major product, but with a lower de when (S)-carvone was used as the substrate. The one-pot reduction was performed at a 0.1 M substrate concentration, indicating that it might provide an effective synthetic route to this type of chiral compound. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SITE-SATURATION MUTAGENESIS ; OLD YELLOW ENZYME ; ASYMMETRIC REDUCTION ; CARBONYL REDUCTASE ; MONOTERPENOID KETONES ; BIOTRANSFORMATION ; ENANTIOSELECTIVITY ; CARVONE ; SPECIFICITY ; (-)-CARVONE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306449900002 |
| 源URL | [http://124.16.173.210/handle/834782/1309]  |
| 专题 | 天津工业生物技术研究所_生物催化与绿色化工 朱敦明_期刊论文 |
| 作者单位 | Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xi,Gao, Xiuzhen,Wu, Qiaqing,et al. Synthesis of optically active dihydrocarveol via a stepwise or one-pot enzymatic reduction of (R)- and (S)-canrone[J]. TETRAHEDRON-ASYMMETRY,2012,23(10):734-738. |
| APA | Chen, Xi,Gao, Xiuzhen,Wu, Qiaqing,&Zhu, Dunming.(2012).Synthesis of optically active dihydrocarveol via a stepwise or one-pot enzymatic reduction of (R)- and (S)-canrone.TETRAHEDRON-ASYMMETRY,23(10),734-738. |
| MLA | Chen, Xi,et al."Synthesis of optically active dihydrocarveol via a stepwise or one-pot enzymatic reduction of (R)- and (S)-canrone".TETRAHEDRON-ASYMMETRY 23.10(2012):734-738. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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