Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2
文献类型：期刊论文
| 作者 | Yang, Beibei1,2,3; Wang, Yu1,2; Chen, Xi1,2; Feng, Jinhui1,2; Wu, Qiaqing1,2; Zhu, Dunming1,2; Ma, Yanhe1,2 |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-01-07 |
| 卷号 | 70期号:1页码:41-46 |
| 关键词 | Steroids Biotransformation Testolactone Testolic acid Penicillium simplicissimum Metabolic pathways |
| 英文摘要 | The biotransformations of a range of steroidal compounds, including 17 alpha-hydroxy progesterone, progesterone, testosterone, androst-4-ene-3,17-dione (AD), pregnenolone, and dehydroepiandrosterone (DHEA), by Penicillium simplicissimum WY134-2 have been investigated. In all the cases, testolic acid and testololactone were detected, and the acid was converted to the lactone when pH was adjusted to 1, leading to isolation of testololactone in 25%-96% yields. Especially for progesterone and testosterone, the isolated yields were 93% and 96% with substrate concentration being 3 g/L, suggesting that P. simplicissimum WY134-2 may be used for the synthesis of testololactone. The results revealed the multi-functional catalytic activity of P. simplicissimum WY134-2 toward steroids for the first time. The possible reaction pathways of steroids promoted by this strain were discussed. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | AROMATASE INHIBITORS ; LACTONIZATION ; 2-METHOXYESTRADIOL ; TRANSFORMATION ; MONOOXYGENASE ; PROGESTERONE ; PURIFICATION ; FUNGUS ; BREAST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330097500005 |
| 源URL | [http://124.16.173.210/handle/834782/1380]  |
| 专题 | 天津工业生物技术研究所_生物催化与绿色化工 朱敦明_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 2.Chinese Acad Sci, Tianjin Engn Ctr Biocatalyt Technol, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Beibei,Wang, Yu,Chen, Xi,et al. Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2[J]. TETRAHEDRON,2014,70(1):41-46. |
| APA | Yang, Beibei.,Wang, Yu.,Chen, Xi.,Feng, Jinhui.,Wu, Qiaqing.,...&Ma, Yanhe.(2014).Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2.TETRAHEDRON,70(1),41-46. |
| MLA | Yang, Beibei,et al."Biotransformations of steroids to testololactone by a multifunctional strain Penicillium simplicissimum WY134-2".TETRAHEDRON 70.1(2014):41-46. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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