Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation
文献类型：期刊论文
| 作者 | Wang, Tao1,2; Sun, Jibin3; Yuan, Jingqi1,2 |
| 刊名 | BIOPROCESS AND BIOSYSTEMS ENGINEERING
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 38期号:4页码:605-614 |
| 关键词 | 2-Keto-L-gulonic acid Mixed culture Fed-batch fermentation Modeling and parameters identification Differential evolution algorithm |
| 英文摘要 | This article presents a modeling approach for industrial 2-keto-L-gulonic acid (2-KGA) fed-batch fermentation by the mixed culture of Ketogulonicigenium vulgare (K. vulgare) and Bacillus megaterium (B. megaterium). A macrokinetic model of K. vulgare is constructed based on the simplified metabolic pathways. The reaction rates obtained from the macrokinetic model are then coupled into a bioreactor model such that the relationship between substrate feeding rates and the main state variables, e.g., the concentrations of the biomass, substrate and product, is constructed. A differential evolution algorithm using the Lozi map as the random number generator is utilized to perform the model parameters identification, with the industrial data of 2-KGA fed-batch fermentation. Validation results demonstrate that the model simulations of substrate and product concentrations are well in coincidence with the measurements. Furthermore, the model simulations of biomass concentrations reflect principally the growth kinetics of the two microbes in the mixed culture. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Engineering, Chemical |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Engineering |
| 关键词[WOS] | MACROKINETIC MODEL ; STOICHIOMETRIC BALANCE ; GLUCONOBACTER-OXYDANS ; L-SORBOSE ; VULGARE ; MEGATERIUM ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351513500001 |
| 源URL | [http://124.16.173.210/handle/834782/1440]  |
| 专题 | 天津工业生物技术研究所_系统与合成生物技术实验室 孙际宾_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Dept Automat, Shanghai 200240, Peoples R China 2.Minist Educ China, Key Lab Syst Control & Informat Proc, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tao,Sun, Jibin,Yuan, Jingqi. Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation[J]. BIOPROCESS AND BIOSYSTEMS ENGINEERING,2015,38(4):605-614. |
| APA | Wang, Tao,Sun, Jibin,&Yuan, Jingqi.(2015).Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation.BIOPROCESS AND BIOSYSTEMS ENGINEERING,38(4),605-614. |
| MLA | Wang, Tao,et al."Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation".BIOPROCESS AND BIOSYSTEMS ENGINEERING 38.4(2015):605-614. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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