Six multicomponent reactions were developed by using aldo-X reagents and -oxoketene dithioacetals with indoles or amines as substrates, which can be used to prepare many heterocycles, such as dihydrocoumarins, quinolines, furans and pyrroles, in a straightforward way. A combination of two bifunctional aldo-X reagents and -oxoketene dithioacetals is the key to make the discovery of these multicomponent reactions possible because these reagents have a minimum of two reactive sites, which enable different substrates to be assembled together in various manners.