CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs)
文献类型：期刊论文
| 作者 | Liu, Ge1,2; Liu, Ming3; Wei JT(魏鉴腾)4 ; Huang, Haijuan5; Zhang, Yuyan5; Zhao, Jin6; Xiao, Lin7; Wu, Ning1; Zheng, Lanhong8; Lin, Xiukun9
|
| 刊名 | Marine Drugs
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:3页码:1530-1544 |
| 关键词 | zebrafish anti-angiogenesis HUVECs CS5931 VEGF and MMPs |
| ISSN号 | 1660-3397 |
| 通讯作者 | Liu, Ming ; Lin, Xiukun |
| 英文摘要 | CS5931 is a novel polypeptide from Ciona savignyi with anticancer activities. Previous study in our laboratory has shown that CS5931 can induce cell death via mitochondrial apoptotic pathway. In the present study, we found that the polypeptide could inhibit angiogenesis both in vitro and in vivo. CS5931 inhibited the proliferation, migration and formation of capillary-like structures of HUVECs (Human Umbilical Vein Endothelial Cell) in a dose-dependent manner. Additionally, CS5931 repressed spontaneous angiogenesis of the zebrafish vessels. Further studies showed that CS5931 also blocked vascular endothelial growth factor (VEGF) production but without any effect on its mRNA expression. Moreover, CS5931 reduced the expression of matrix metalloproteinases (MMP-2 and MMP-9) both on protein and mRNA levels in HUVEC cells. We demonstrated that CS5931 possessed strong anti-angiogenic activity both in vitro and in vivo, possible via VEGF and MMPs. This study indicates that CS5931 has the potential to be developed as a novel therapeutic agent as an inhibitor of angiogenesis for the treatment of cancer. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | National Innovative Drugs Development program of China (No. 2014ZX-091022043-0001);863 High Technology Project (No. 2014AA093503);the National Natural Science Foundation of China (No. 81001396;No. 81273550;No. 41306157);International Cooperation project of China-Israel (2013DFG33000) |
| 语种 | 英语 |
| WOS记录号 | WOS:000335752800023 |
| 源URL | [http://210.77.64.217/handle/362003/20327]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 5.Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China 6.Zhengzhou Univ, Dept Biotechnol, Zhengzhou 450001, Peoples R China 7.Qingdao Agr Univ, Qingdao 266109, Peoples R China 8.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 9.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ge,Liu, Ming,Wei JT,et al. CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs)[J]. Marine Drugs,2014,12(3):1530-1544. |
| APA | Liu, Ge.,Liu, Ming.,Wei JT.,Huang, Haijuan.,Zhang, Yuyan.,...&Lin, Xiukun.(2014).CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs).Marine Drugs,12(3),1530-1544. |
| MLA | Liu, Ge,et al."CS5931, a Novel Polypeptide in Ciona savignyi, Represses Angiogenesis via Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs)".Marine Drugs 12.3(2014):1530-1544. |
入库方式： OAI收割
来源：兰州化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。