Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets
文献类型：期刊论文
| 作者 | Su, S; Sun, HF; Cao, WF; Chao, J; Peng, HZ; Zuo, XL; Yuwen, LH; Fan, CH; Wang, LH |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:11页码:6826—6833 |
| 关键词 | SINGLE-LAYER MOS2 MOLYBDENUM-DISULFIDE ADENOSINE-TRIPHOSPHATE SIGNAL AMPLIFICATION SENSITIVE DETECTION THROMBIN DETECTION GRAPHENE OXIDE APTAMER LABEL APTASENSOR |
| ISSN号 | 1944-8244 |
| 通讯作者 | Su, S ; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China. ; Su, S ; Wang, LH (reprint author), Nanjing Univ Posts & Telecommun, Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China. |
| 英文摘要 | A MoS2-based electrochemical aptasensor has been developed for the simultaneous detection of thrombin and adenosine triphosphate (ATP) based on gold nano particles-decorated MoS2 (AuNPs-MoS2) nanocomposites. Two different aptamer probes labeled with redox tags were simultaneously immobilized on an AuNPs-MoS2 film modified electrode via Au-S bonds. The aptamers presented structural switches with the addition of target molecules (thrombin and ATP), resulting in methylene blue (MB) far from or ferrocene (Fc) close to the electrode surface. Therefore, a dual signaling detection strategy was developed, which featured both "signal-on" and "signal-off' elements in the detection system because of the target-induced structure switching. This proposed aptasensor could simultaneously determine ATP and thrombin as low as 0.74 nM ATP and 0.0012 nM thrombin with high selectivity, respectively. In addition, thrombin and ATP could act as inputs to activate an AND logic gate. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372946600007 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25691]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Su, S,Sun, HF,Cao, WF,et al. Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(11):6826—6833. |
| APA | Su, S.,Sun, HF.,Cao, WF.,Chao, J.,Peng, HZ.,...&Wang, LH.(2016).Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets.ACS APPLIED MATERIALS & INTERFACES,8(11),6826—6833. |
| MLA | Su, S,et al."Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets".ACS APPLIED MATERIALS & INTERFACES 8.11(2016):6826—6833. |
入库方式： OAI收割
来源：上海应用物理研究所
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