Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study
文献类型：期刊论文
| 作者 | Zhao, JF; Liu, YC; Jiang, XX; Guo, P; Xu, YL; Zhang, P; Ji, TY; Lin, ZS; Wang, WF |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 155期号:-页码:122—129 |
| 关键词 | NEUTRAL AQUEOUS-SOLUTION FLUOROQUINOLONE ANTIBIOTICS MYCOBACTERIUM-TUBERCULOSIS STREPTOCOCCUS-PNEUMONIAE QUINOLONE ANTIBACTERIALS SPECTROSCOPIC PROPERTIES PHOTOPHYSICAL PROPERTIES DRUG LOMEFLOXACIN ELECTRON-TRANSFER STEADY-STATE |
| ISSN号 | 1011-1344 |
| 通讯作者 | Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. ; Lin, ZS (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Ctr Crystal R&D, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China. |
| 英文摘要 | The photochemistry of two structure-related fluoroquinolones (FQs), antofloxacin (ANT) and levofloxacin (LEV), was studied in aqueous solution using stable and transient methods. The properties for energy transfer and electron transfer of these two FQs were also studied. The transient absorption spectra of FQs were observed, and transient species were assigned. The LEV triplet state ((LEV)-L-3*) spectra (lambda(max) = 610 nm) were determined, whereas the transient absorption of ANT could not be observed. The decay rate constant of (LEV)-L-3* via unimolecular attenuation, self-quenching, and quenching by oxygen was 32 x 10(5) s(-1), 6.72 x 10(8) M-1 s(-1), and 1.01 x 10(9) M-1 s(-1), respectively. A reasonable diagram showing the decay of (1)FQs* consisting of various substituents at the C-5 position was proposed. The phototoxicity of LEV and ANT was investigated and compared. Insertion of an amino group at the C-5 position made ANT relatively photostable and non-phototoxic compared with LEV. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000370090700017 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25693]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhao, JF,Liu, YC,Jiang, XX,et al. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2016,155(-):122—129. |
| APA | Zhao, JF.,Liu, YC.,Jiang, XX.,Guo, P.,Xu, YL.,...&Wang, WF.(2016).Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,155(-),122—129. |
| MLA | Zhao, JF,et al."Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 155.-(2016):122—129. |
入库方式： OAI收割
来源：上海应用物理研究所
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