Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer
文献类型：期刊论文
| 作者 | Pan, YW; Zhang, L; Zeng, LY; Ren, WZ; Xiao, XS; Zhang, JC; Zhang, LL; Li, AG; Lu, GM; Wu, AG |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:2页码:878—888 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES IN-VIVO PHOTODYNAMIC THERAPY MAGNETIC-RESONANCE DRUG-DELIVERY TIO2 NANOCARRIERS DOXORUBICIN LUMINESCENT NANOCOMPOSITES CELLS |
| ISSN号 | 2040-3364 |
| 通讯作者 | Zeng, LY (reprint author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. |
| 英文摘要 | Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk-shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core-shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk-shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367258500023 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25732]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Pan, YW,Zhang, L,Zeng, LY,et al. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer[J]. NANOSCALE,2016,8(2):878—888. |
| APA | Pan, YW.,Zhang, L.,Zeng, LY.,Ren, WZ.,Xiao, XS.,...&Wu, AG.(2016).Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer.NANOSCALE,8(2),878—888. |
| MLA | Pan, YW,et al."Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer".NANOSCALE 8.2(2016):878—888. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。