Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging
文献类型：期刊论文
| 作者 | Hu, CY; Shen, JL; Yan, J; Zhong, J; Qin, WW; Liu, R; Aldalbahi, A; Zuo, XL; Song, SP; Fan, CH |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:4页码:2090—2096 |
| 关键词 | SINGLE-MOLECULE SERS HOT-SPOTS GOLD NANOPARTICLES LIVE CELLS SCATTERING SPECTROSCOPY TAGS DNA CYTOTOXICITY LOCALIZATION |
| ISSN号 | 2040-3364 |
| 通讯作者 | He, DN (reprint author), Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China. ; Yan, J (reprint author), Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China. |
| 英文摘要 | Cellular imaging technologies employing metallic surface-enhanced Raman scattering (SERS) tags have gained much interest toward clinical diagnostics, but they are still suffering from poor controlled distribution of hot spots and reproducibility of SERS signals. Here, we report the fabrication and characterization of high narrow nanogap-containing Au@Au core-shell SERS nanoparticles (GCNPs) for the identification and imaging of proteins overexpressed on the surface of cancer cells. First, plasmonic nanostructures are made of gold nanoparticles (similar to 15 nm) coated with gold shells, between which a highly narrow and uniform nanogap (similar to 1.1 nm) is formed owing to polyA anchored on the Au cores. The well controlled distribution of Raman reporter molecules, such as 4,4'-dipyridyl (44DP) and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), are readily encoded in the nanogap and can generate strong, reproducible SERS signals. In addition, we have investigated the size-dependent SERS activity of GCNPs and found that with the same laser wavelength, the Raman enhancement discriminated between particle sizes. The maximum Raman enhancement was achieved at a certain threshold of particle size (similar to 76 nm). High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. And it was shown that GCTs have a good targeting ability to tumour cells and promising prospects for multiplex biomarker detection. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368860900039 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25743]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Hu, CY,Shen, JL,Yan, J,et al. Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging[J]. NANOSCALE,2016,8(4):2090—2096. |
| APA | Hu, CY.,Shen, JL.,Yan, J.,Zhong, J.,Qin, WW.,...&He, DN.(2016).Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging.NANOSCALE,8(4),2090—2096. |
| MLA | Hu, CY,et al."Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging".NANOSCALE 8.4(2016):2090—2096. |
入库方式： OAI收割
来源：上海应用物理研究所
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