The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
文献类型：期刊论文
| 作者 | Zhang, XM; Dai, LR; Wang, AH; Wolk, C; Dobner, B; Brezesinski, G; Tang, YQ; Wang, XY; Li, JB |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:0页码:16559 |
| 通讯作者 | Li, JB (reprint author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China. |
| 英文摘要 | Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second), and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | ENDOPLASMIC-RETICULUM ; GENE DELIVERY ; LIVING CELLS ; CATIONIC LIPOSOMES ; TRANSPORT ; LIPIDS ; MICROTUBULES ; TRAFFICKING ; BEHAVIOR ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/20797]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Zhang, XM,Dai, LR,Wang, AH,et al. The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes[J]. SCIENTIFIC REPORTS,2015,5(0):16559. |
| APA | Zhang, XM.,Dai, LR.,Wang, AH.,Wolk, C.,Dobner, B.,...&Li, JB.(2015).The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes.SCIENTIFIC REPORTS,5(0),16559. |
| MLA | Zhang, XM,et al."The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes".SCIENTIFIC REPORTS 5.0(2015):16559. |
入库方式： OAI收割
来源：理论物理研究所
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