Optimal aspect ratio of endocytosed spherocylindrical nanoparticle
文献类型：期刊论文
| 作者 | Chen, YB; Liu, YH; Zeng, Y; Mao, W; Hu, L; Mao, ZL; Xu, HQ |
| 刊名 | FRONTIERS OF PHYSICS
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:1页码:116-120 |
| 关键词 | cellular uptake depletion effects dimension of ligand-receptor complex elasticity theory |
| 通讯作者 | Liu, YH (reprint author), Guizhou Univ, Coll Anim Sci, Minist Educ, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Peoples R China. |
| 英文摘要 | Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design. |
| 学科主题 | Physics |
| 类目[WOS] | Physics, Multidisciplinary |
| 关键词[WOS] | RECEPTOR-MEDIATED ENDOCYTOSIS ; CELLS ; MECHANICS ; SHAPES |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/21104]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 推荐引用方式 GB/T 7714 | Chen, YB,Liu, YH,Zeng, Y,et al. Optimal aspect ratio of endocytosed spherocylindrical nanoparticle[J]. FRONTIERS OF PHYSICS,2015,10(1):116-120. |
| APA | Chen, YB.,Liu, YH.,Zeng, Y.,Mao, W.,Hu, L.,...&Xu, HQ.(2015).Optimal aspect ratio of endocytosed spherocylindrical nanoparticle.FRONTIERS OF PHYSICS,10(1),116-120. |
| MLA | Chen, YB,et al."Optimal aspect ratio of endocytosed spherocylindrical nanoparticle".FRONTIERS OF PHYSICS 10.1(2015):116-120. |
入库方式： OAI收割
来源：理论物理研究所
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