Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging
文献类型：期刊论文
| 作者 | Jiang, DW; Sun, YH; Li, J; Li, Q; Lv, M; Zhu, B; Tian, T; Cheng, DF; Xia, JY; Zhang, L |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:7页码:4378—4384 |
| 关键词 | QUANTUM DOTS MULTIFUNCTIONAL NANOPARTICLES INORGANIC NANOPARTICLES CARBON NANOTUBES CANCER-THERAPY DELIVERY STABILITY SPECT PET NANOTECHNOLOGY |
| ISSN号 | 1944-8244 |
| 通讯作者 | Sun, YH ; Zhang, L ; Wang, LH (reprint author), Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China. ; Sun, YH ; Zhang, L ; Wang, LH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China. |
| 英文摘要 | In this work, we have developed multiple-armed DNA tetrahedral nanostructures (TDNs) for dual-modality in vivo imaging using near-infrared (NIR) fluorescence and single-photon emission computed tomography (SPECT). We found that the presence of arm strands in TDNs remarkably enhanced their in vitro stability, allowing them to stay intact for at least 12 h in serum. By using NIR fluorescence imaging, we evaluated in mice the pharmacokinetics of TDNs, which exhibited distinctly different in vivo biodistribution patterns compared with those of double-stranded (ds)DNA. We also noticed that TDNs had twofold longer circulation time in the blood system than that of dsDNA. With the use of multiple armed TDNs, we could precisely anchor an exact number of functional groups including tumor-targeting folic acid (FA), NIR emitter Dylight 755, and radioactive isotope Tc-99m on prescribed positions of TDNs, which showed the capability of targeted imaging ability in cancer cells. Furthermore, we realized noninvasive tumor-targeting imaging in tumor-bearing mice by using both NIR and SPECT modalities. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371105800015 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25778]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Jiang, DW,Sun, YH,Li, J,et al. Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(7):4378—4384. |
| APA | Jiang, DW.,Sun, YH.,Li, J.,Li, Q.,Lv, M.,...&Fan, CH.(2016).Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging.ACS APPLIED MATERIALS & INTERFACES,8(7),4378—4384. |
| MLA | Jiang, DW,et al."Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging".ACS APPLIED MATERIALS & INTERFACES 8.7(2016):4378—4384. |
入库方式： OAI收割
来源：上海应用物理研究所
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