Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
文献类型：期刊论文
| 作者 | Cui, ZF; Zhang, Y; Zhang, JC; Kong, HT; Tang, XX; Pan, L; Xia, K; Aldalbahi, A; Li, AG; Tai, RZ |
| 刊名 | CARBON
 |
| 出版日期 | 2016 |
| 卷号 | 97期号:-页码:78—86 |
| 关键词 | ANTITUMOR-ACTIVITY CARBON NANOTUBES CANCER-THERAPY DELIVERY CISPLATIN NANOCARRIER CELLS BIOCOMPATIBILITY THERAPEUTICS ACCUMULATION |
| ISSN号 | 0008-6223 |
| 通讯作者 | Zhang, JC (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China. |
| 英文摘要 | Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366939900008 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25835]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Cui, ZF,Zhang, Y,Zhang, JC,et al. Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors[J]. CARBON,2016,97(-):78—86. |
| APA | Cui, ZF.,Zhang, Y.,Zhang, JC.,Kong, HT.,Tang, XX.,...&Zhu, Y.(2016).Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors.CARBON,97(-),78—86. |
| MLA | Cui, ZF,et al."Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors".CARBON 97.-(2016):78—86. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。