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The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons
文献类型：期刊论文
| 作者 | Zhang, QQ; Zhang, Y; Wang, CY; Xu, ZJ; Liang, QF; An, L; Li, JW; Liu, ZD; You, Y; He, M |
| 刊名 | Cell Reports
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:5页码:1431-1444 |
| 关键词 | LATERAL GANGLIONIC EMINENCE MEDIUM SPINY NEURONS STRIATAL INTERNEURONS GENE-EXPRESSION BASAL GANGLIA SUBVENTRICULAR ZONE HUNTINGTONS-DISEASE CRE RECOMBINASE GENOME-WIDE STEM-CELLS |
| 通讯作者 | Yang, ZG (reprint author), Fudan Univ, Inst Brain Sci, Collaborat Innovat Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China. ; Yang, ZG (reprint author), Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China.,yangz@fudan.edu.cn |
| 英文摘要 | Striatal medium-sized spiny neurons (MSNs), composed of striatonigral and striatopallidal neurons, are derived from the lateral ganglionic eminence (LGE). We find that the transcription factor Sp9 is expressed in LGE progenitors that generate nearly all striatal MSNs and that Sp9 expression is maintained in postmitotic striatopallidal MSNs. Sp9-null mice lose most striatopallidal MSNs because of decreased proliferation of striatopallidal MSN progenitors and increased Bax-dependent apoptosis, whereas the development of striatonigral neurons is largely unaffected. ChIP qPCR provides evidence that Ascl1 directly binds the Sp9 promoter. RNA-seq and in situ hybridization reveal that Sp9 promotes expression of Adora2a, P2ry1, Gpr6, and Grik3 in the LGE and striatum. Thus, Sp9 is crucial for the generation, differentiation, and survival of striatopallidal MSNs. |
| 学科主题 | Cell Biology |
| WOS标题词 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000380749200022 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4009]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, QQ,Zhang, Y,Wang, CY,et al. The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons[J]. Cell Reports,2016,16(5):1431-1444. |
| APA | Zhang, QQ.,Zhang, Y.,Wang, CY.,Xu, ZJ.,Liang, QF.,...&Yang, ZG.(2016).The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.Cell Reports,16(5),1431-1444. |
| MLA | Zhang, QQ,et al."The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons".Cell Reports 16.5(2016):1431-1444. |
入库方式： OAI收割
来源：上海神经科学研究所
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