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Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion
文献类型：期刊论文
| 作者 | Guo, YM; Wang, YP; Zhang, W; Meltzer, S; Zanini, D; Yu, Y; Li, JF; Cheng, T; Guo, ZH; Wang, QX |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2016 |
| 卷号 | 113期号:26页码:7243-7248 |
| 关键词 | CELL MECHANOTRANSDUCER CHANNELS MULTIDENDRITIC SENSORY NEURONS COCHLEAR HAIR-CELLS C. ELEGANS MECHANICAL NOCICEPTION DEG/ENAC CHANNEL TRP CHANNELS HEARING-LOSS INNER-EAR NOMPC |
| 通讯作者 | Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94158 USA. ; Jan, YN (reprint author), Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94158 USA.,yuhnung.jan@ucsf.edu ; zuorenwang@ion.ac.cn |
| 英文摘要 | Drosophila larval locomotion, which entails rhythmic body contractions, is controlled by sensory feedback from proprioceptors. The molecular mechanisms mediating this feedback are little understood. By using genetic knock-in and immunostaining, we found that the Drosophila melanogaster transmembrane channel-like (tmc) gene is expressed in the larval class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons, both of which are known to provide sensory feedback for larval locomotion. Larvae with knockdown or loss of tmc function displayed reduced crawling speeds, increased head cast frequencies, and enhanced backward locomotion. Expressing Drosophila TMC or mammalian TMC1 and/or TMC2 in the tmc-positive neurons rescued these mutant phenotypes. Bending of the larval body activated the tmc-positive neurons, and in tmc mutants this bending response was impaired. This implicates TMC's roles in Drosophila proprioception and the sensory control of larval locomotion. It also provides evidence for a functional conservation between Drosophila and mammalian TMCs. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000379033400072 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4017]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Guo, YM,Wang, YP,Zhang, W,et al. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(26):7243-7248. |
| APA | Guo, YM.,Wang, YP.,Zhang, W.,Meltzer, S.,Zanini, D.,...&Wang, ZR.(2016).Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(26),7243-7248. |
| MLA | Guo, YM,et al."Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.26(2016):7243-7248. |
入库方式： OAI收割
来源：上海神经科学研究所
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