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Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
文献类型:期刊论文
作者 | Wu, KY; Zuo, GL; Li, XF; Ye, Q; Deng, YQ; Huang, XY; Cao, WC; Qin, CF; Luo, ZG |
刊名 | CELL RESEARCH |
出版日期 | 2016 |
卷号 | 26期号:6页码:645-654 |
关键词 | INFECTION AUTISM BRAZIL BRAIN PROGENITORS NEOCORTEX AMERICA |
通讯作者 | Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. ; Qin, CF (reprint author), Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. ; Luo, ZG (reprint author), Chinese Acad Sci Univ, Beijing, Peoples R China. ; Luo, ZG (reprint author), ShanghaiTech Univ, Shanghai, Peoples R China.,qincf@bmi.ac.cn ; zgluo@ion.ac.cn |
英文摘要 | The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies. |
学科主题 | Cell Biology |
WOS标题词 | Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000377449500005 |
源URL | [http://ir.sibs.ac.cn/handle/331001/4019] |
专题 | 上海神经科学研究所_神经所(总) |
推荐引用方式 GB/T 7714 | Wu, KY,Zuo, GL,Li, XF,et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice[J]. CELL RESEARCH,2016,26(6):645-654. |
APA | Wu, KY.,Zuo, GL.,Li, XF.,Ye, Q.,Deng, YQ.,...&Luo, ZG.(2016).Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.CELL RESEARCH,26(6),645-654. |
MLA | Wu, KY,et al."Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice".CELL RESEARCH 26.6(2016):645-654. |
入库方式: OAI收割
来源:上海神经科学研究所
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