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Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination
文献类型：期刊论文
| 作者 | Popescu, AT; Zhou, MR; Poo, MM |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2016 |
| 卷号 | 113期号:22页码:E3169-E3176 |
| 关键词 | VENTRAL TEGMENTAL AREA FRONTO-EXECUTIVE FUNCTION LATENT INHIBITION NUCLEUS-ACCUMBENS SYNAPTIC PLASTICITY NEURONS MODULATION RAT REWARD MECHANISMS |
| 通讯作者 | Popescu, AT ; Poo, MM (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA. ; Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,popescu@berkeley.edu ; mpoo@ion.ac.cn |
| 英文摘要 | Phasic dopamine (DA) release is believed to guide associative learning. Most studies have focused on projections from the ventral tegmental area (VTA) to the striatum, and the action of DA in other VTA target regions remains unclear. Using optogenetic activation of VTA projections, we examined DA function in the medial prefrontal cortex (mPFC). We found that mice perceived optogenetically induced DA release in mPFC as neither rewarding nor aversive, and did not change their previously learned behavior in response to DA transients. However, repetitive temporal pairing of an auditory conditioned stimulus (CS) with mPFC DA release resulted in faster learning of a subsequent task involving discrimination of the same CS against unpaired stimuli. Similar results were obtained using both appetitive and aversive unconditioned stimuli, supporting the notion that DA transients in mPFC do not represent valence. Using extracellular recordings, we found that CS-DA pairings increased firing of mPFC neurons in response to CSs, and administration of D-1 or D-2 DAreceptor antagonists in mPFC during learning impaired stimulus discrimination. We conclude that DA transients tune mPFC neurons for the recognition of behaviorally relevant events during learning. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000376784600017 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4020]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Popescu, AT,Zhou, MR,Poo, MM. Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(22):E3169-E3176. |
| APA | Popescu, AT,Zhou, MR,&Poo, MM.(2016).Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(22),E3169-E3176. |
| MLA | Popescu, AT,et al."Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.22(2016):E3169-E3176. |
入库方式： OAI收割
来源：上海神经科学研究所
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