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Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
文献类型：期刊论文
| 作者 | Liu, QQ; Yang, X; Tian, JS; Gao, ZB; Wang, M; Li, Y; Guo, AK |
| 刊名 | ELIFE
 |
| 出版日期 | 2016 |
| 卷号 | 5页码:e13238 |
| 关键词 | CONNEXIN PHOSPHORYLATION ELECTRICAL SYNAPSES VITAMIN-A SYSTEM NEURONS CELLS INTERNEURONS MELANOGASTER INHIBITION NEUROBLAST |
| 通讯作者 | Li, Y ; Guo, AK (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China. ; Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci,Inst Neurosci, Shanghai, Peoples R China.,yanli42@126.com ; akguo@ion.ac.cn |
| 英文摘要 | Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly's visual learning and memory. |
| WOS标题词 | Life Sciences & Biomedicine - Other Topics |
| 学科主题 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000378777300001 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4021]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, QQ,Yang, X,Tian, JS,et al. Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila[J]. ELIFE,2016,5:e13238. |
| APA | Liu, QQ.,Yang, X.,Tian, JS.,Gao, ZB.,Wang, M.,...&Guo, AK.(2016).Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila.ELIFE,5,e13238. |
| MLA | Liu, QQ,et al."Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila".ELIFE 5(2016):e13238. |
入库方式： OAI收割
来源：上海神经科学研究所
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